| pubmed-article:7533901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7533901 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:7533901 | lifeskim:mentions | umls-concept:C0600115 | lld:lifeskim |
| pubmed-article:7533901 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:7533901 | lifeskim:mentions | umls-concept:C0449851 | lld:lifeskim |
| pubmed-article:7533901 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:7533901 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:7533901 | lifeskim:mentions | umls-concept:C1517503 | lld:lifeskim |
| pubmed-article:7533901 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7533901 | pubmed:dateCreated | 1995-4-11 | lld:pubmed |
| pubmed-article:7533901 | pubmed:abstractText | A new modeling technique for arriving at the three dimensional (3-D) structure of an RNA stem-loop has been developed based on a conformational search by a genetic algorithm and the following refinement by energy minimization. The genetic algorithm simultaneously optimizes a population of conformations in the predefined conformational space and generates 3-D models of RNA. The fitness function to be optimized by the algorithm has been defined to reflect the satisfaction of known conformational constraints. In addition to a term for distance constraints, the fitness function contains a term to constrain each local conformation near to a prepared template conformation. The technique has been applied to the two loops of tRNA, the anticodon loop and the T-loop, and has found good models with small root mean square deviations from the crystal structure. Slightly different models have also been found for the anticodon loop. The analysis of a collection of alternative models obtained has revealed statistical features of local variations at each base position. | lld:pubmed |
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| pubmed-article:7533901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7533901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7533901 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7533901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7533901 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7533901 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:7533901 | pubmed:author | pubmed-author:OgataHH | lld:pubmed |
| pubmed-article:7533901 | pubmed:author | pubmed-author:AkiyamaYY | lld:pubmed |
| pubmed-article:7533901 | pubmed:author | pubmed-author:KanehisaMM | lld:pubmed |
| pubmed-article:7533901 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7533901 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:7533901 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:7533901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7533901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7533901 | pubmed:pagination | 419-26 | lld:pubmed |
| pubmed-article:7533901 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7533901 | pubmed:meshHeading | pubmed-meshheading:7533901-... | lld:pubmed |
| pubmed-article:7533901 | pubmed:meshHeading | pubmed-meshheading:7533901-... | lld:pubmed |
| pubmed-article:7533901 | pubmed:meshHeading | pubmed-meshheading:7533901-... | lld:pubmed |
| pubmed-article:7533901 | pubmed:meshHeading | pubmed-meshheading:7533901-... | lld:pubmed |
| pubmed-article:7533901 | pubmed:meshHeading | pubmed-meshheading:7533901-... | lld:pubmed |
| pubmed-article:7533901 | pubmed:meshHeading | pubmed-meshheading:7533901-... | lld:pubmed |
| pubmed-article:7533901 | pubmed:meshHeading | pubmed-meshheading:7533901-... | lld:pubmed |
| pubmed-article:7533901 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7533901 | pubmed:articleTitle | A genetic algorithm based molecular modeling technique for RNA stem-loop structures. | lld:pubmed |
| pubmed-article:7533901 | pubmed:affiliation | Institute for Chemical Research, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:7533901 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7533901 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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