Linked Life Data

7531676

Source:http://linkedlifedata.com/resource/pubmed/id/7531676

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pubmed-article:7531676pubmed:abstractTextThe 45-69 peptide, an helper T-cell epitope derived from the HIV nef protein is strongly immunogenic. A T-cell proliferative response was observed following immunization of Lou/M rats with 45-69 peptide administered in low dose and without any adjuvant. It is already known that the T-cell response to the 115-131 peptide of Sm28GST antigen, a protein of the parasite Schistosoma mansoni, requires the presence of a carrier of the use of peptidic constructs. We demonstrate here that a T-cell response against the 115-131 peptide can be obtained in the absence of adjuvant using peptidic constructs (115-45 and 45-115 peptides) resulting from tandem synthesis of 115-131 and 45-69 peptides. A covalent association of both peptides is necessary, since the coinjection of 45-69 and 115-131 peptides is not sufficient to induce a detectable anti-115-131 T-cell response. The mutual orientation between the respective tandem peptides (45-115 and 115-45) is critical for the T-cell response. These peptidic constructs possess distinct properties of antigenicity and immunogenicity but both allowed to reveal the existence of a specific T-cell response normally undetectable using 115-131 peptide alone. This immunopharmacological approach should be useful in the rational design and construction of vaccines.lld:pubmed
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pubmed-article:7531676pubmed:pagination215-22lld:pubmed
pubmed-article:7531676pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:7531676pubmed:articleTitleImprovement of the T-cell response to a non immunogenic peptide by its tandem association with a highly efficient T-helper peptide.lld:pubmed
pubmed-article:7531676pubmed:affiliationCentre d'Immunologie des Maladies Transmissibles et Allergiques, Unité mixte INSERM U167-CNRS 624, Institut Pasteur de Lille, France.lld:pubmed
pubmed-article:7531676pubmed:publicationTypeJournal Articlelld:pubmed