| pubmed-article:7531647 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7531647 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:7531647 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:7531647 | lifeskim:mentions | umls-concept:C0001492 | lld:lifeskim |
| pubmed-article:7531647 | lifeskim:mentions | umls-concept:C0060993 | lld:lifeskim |
| pubmed-article:7531647 | lifeskim:mentions | umls-concept:C0379900 | lld:lifeskim |
| pubmed-article:7531647 | lifeskim:mentions | umls-concept:C0597359 | lld:lifeskim |
| pubmed-article:7531647 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7531647 | lifeskim:mentions | umls-concept:C2699782 | lld:lifeskim |
| pubmed-article:7531647 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7531647 | pubmed:dateCreated | 1995-3-10 | lld:pubmed |
| pubmed-article:7531647 | pubmed:abstractText | We have studied the coupling of galanin and 5-HT1A receptors with adenylyl cyclase in the hypothalamus, the entorhinal cortex and the hippocampus of the rat brain. Furthermore, we have evaluated the effects of simultaneous activation of galanin and 5-HT1A receptors on adenylyl cyclase activity. Galanin-(1-29) and galanin-(1-15) showed a dose-dependent inhibitory effect on forskolin-stimulated adenylyl cyclase activity in the hypothalamus and entorhinal cortex. No clear effects were observed in the hippocampus. Neither galanin-(1-29) nor galanin-(1-15) had any effect on the basal activity of adenylyl cyclase in these regions. The selective 5-HT1A receptor agonist 8-OH-2-(di-n-propylamino)-tetralin (8-OH-DPAT) induced a dose-dependent inhibition of forskolin stimulated adenylyl cyclase activity in the hippocampus and the entorhinal cortex. 5-HT induced an inhibition in the hypothalamus. In all regions the effects could be fully counteracted by methiothepin. 5-HT was shown to stimulate the basal activity of adenylyl cyclase in the hippocampus and the entorhinal cortex. The effects could be counteracted by methiothepin. When galanin-(1-29) and 5-HT/8-OH-DPAT were incubated simultaneously additive inhibitory effects, but no synergistic interactions, could be observed on the stimulated adenylyl cyclase activity. In conclusion, galanin and 5-HT1A receptors seem to be linked to different independent pools of G proteins, indicating that the previously demonstrated intramembrane interactions between galanin and 5-HT1A receptors involve a mechanism not directly related to adenylyl cyclase. | lld:pubmed |
| pubmed-article:7531647 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7531647 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531647 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7531647 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7531647 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:7531647 | pubmed:author | pubmed-author:FillionGG | lld:pubmed |
| pubmed-article:7531647 | pubmed:author | pubmed-author:BillecocqAA | lld:pubmed |
| pubmed-article:7531647 | pubmed:author | pubmed-author:HedlundP BPB | lld:pubmed |
| pubmed-article:7531647 | pubmed:author | pubmed-author:Bolaños-Jimén... | lld:pubmed |
| pubmed-article:7531647 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7531647 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:7531647 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:7531647 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7531647 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7531647 | pubmed:pagination | 209-17 | lld:pubmed |
| pubmed-article:7531647 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7531647 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7531647 | pubmed:articleTitle | Characterization of galanin and 5-HT1A receptor coupling to adenylyl cyclase in discrete regions of the rat brain. | lld:pubmed |
| pubmed-article:7531647 | pubmed:affiliation | Unit of Neuroimmunoendocrinological Pharmacology, Institut Pasteur, Paris, France. | lld:pubmed |
| pubmed-article:7531647 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7531647 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7531647 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7531647 | lld:pubmed |
