| pubmed-article:7531516 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7531516 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7531516 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:7531516 | lifeskim:mentions | umls-concept:C1517162 | lld:lifeskim |
| pubmed-article:7531516 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:7531516 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7531516 | lifeskim:mentions | umls-concept:C0249989 | lld:lifeskim |
| pubmed-article:7531516 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:7531516 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7531516 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7531516 | pubmed:dateCreated | 1995-3-16 | lld:pubmed |
| pubmed-article:7531516 | pubmed:abstractText | The effects of the recently identified FLK-2/FLT-3 ligand (FL) on the growth of purified human fetal liver progenitors were investigated under serum-deprived culture conditions. FL alone was found to stimulate modest proliferation in short-term cultures of CD34++ CD38+ lineage (Lin)- light-density fetal liver (LDFL) cells and the more primitive CD34++ CD38- Lin- LDFL cells. However, the low levels of growth induced by FL were insufficient for colony formation in clonal cultures. Synergism between FL and either granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) or KIT ligand (KL) was observed in promoting the growth of high-proliferative potential (HPP) colony-forming cells (CF) and/or low-proliferative potential (LPP)-CFC in cultures of CD34++ CD38+ Lin- and CD34++ CD38- Lin- LDFL-cells. FL, alone or in combination with other cytokines, was not found to affect the growth of CD34+ Lin- LDFL cells, the most mature subpopulation of fetal liver progenitors investigated. The growth of the most primitive subset of progenitors studied, CD34++ CD38- Lin- LDFL cells, required the interactions of at least two cytokines, because only very low levels of growth were observed in response to either FL, GM-CSF, IL-3 or KL alone. However, the results of delayed cytokine-addition experiments suggested that individually these cytokines did promote the survival of this early population of progenitors. Although two-factor combinations of FL, KL, and GM-CSF were observed to promote the growth of early progenitors in a synergistic manner, neither of these factors was found to make fetal liver progenitors more responsive to suboptimal concentrations of a second cytokine. Only myeloid cells were recovered from liquid cultures of CD34++ CD38- Lin- LDFL cells grown in the presence of combinations of FL, KL, and GM-CSF. These results indicate that FL is part of a network of growth factors that regulate the growth and survival of early hematopoietic progenitors. | lld:pubmed |
| pubmed-article:7531516 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7531516 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7531516 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7531516 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7531516 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:LeeFF | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:MenonSS | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:XuYY | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:HannumC HCH | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:RoncaroloM... | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:MuenchM OMO | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:NamikawaRR | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:KasteleinRR | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:CulpepperJJ | lld:pubmed |
| pubmed-article:7531516 | pubmed:author | pubmed-author:ZurawskiSS | lld:pubmed |
| pubmed-article:7531516 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7531516 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7531516 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:7531516 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7531516 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7531516 | pubmed:pagination | 963-72 | lld:pubmed |
| pubmed-article:7531516 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7531516 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7531516 | pubmed:articleTitle | FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. | lld:pubmed |
| pubmed-article:7531516 | pubmed:affiliation | Human Immunology and Molecular Biology Departments, DNAX Research Institute, Palo Alto, CA. | lld:pubmed |
| pubmed-article:7531516 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7531516 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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