Linked Life Data

7530227

Source:http://linkedlifedata.com/resource/pubmed/id/7530227

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:7530227rdf:typepubmed:Citationlld:pubmed
pubmed-article:7530227lifeskim:mentionsumls-concept:C0043393lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0020517lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0025252lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0017337lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0026882lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0010592lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0018270lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0679622lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C2700640lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0205314lld:lifeskim
pubmed-article:7530227lifeskim:mentionsumls-concept:C0729218lld:lifeskim
pubmed-article:7530227pubmed:issue1-2lld:pubmed
pubmed-article:7530227pubmed:dateCreated1995-2-22lld:pubmed
pubmed-article:7530227pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:abstractTextFK506 and cyclosporin A (CsA) are potent immunosuppressive agents that display antifungal activity. They act by blocking a Ca(2+)-dependent signal transduction pathway leading to interleukin-2 transcription. Each drug forms a complex with its cognate cytosolic immunophilin receptor (i.e., FKBP12-FK506 and cyclophilin-CsA) which acts to inhibit the Ca2+/calmodulin-dependent protein phosphatase 2B, or calcineurin (CN). We and others have defined the Saccharomyces cerevisiae FKS1 gene by recessive mutations resulting in 100-1000-fold hypersensitivity to FK506 and CsA (as compared to wild type), but which do not affect sensitivity to a variety of other antifungal drugs. The fks1 mutant also exhibits a slow-growth phenotype that can be partially alleviated by exogenously added Ca2+ [Parent et al., J. Gen. Microbiol. 139 (1993) 2973-2984]. We have cloned FKS1 by complementation of the drug-hypersensitive phenotype. It contains a long open reading frame encoding a novel 1876-amino-acid (215 kDa) protein which shows no similarity to CN or to other protein phosphatases. The FKS1 protein is predicted to contain 10 to 12 transmembrane domains with a structure resembling integral membrane transporter proteins. Genomic disruption experiments indicate that FKS1 encodes a nonessential function; fks1::LEU2 cells exhibit the same growth and recessive drug-hypersensitive phenotypes observed in the original fks1 mutants. Furthermore, the fks1::LEU2 allele is synthetically lethal in combination with disruptions of both of the nonessential genes encoding the alternative forms of the catalytic A subunit of CN (CNA1 and CNA2). These data suggest that FKS1 provides a unique cellular function which, when absent, increases FK506 and CsA sensitivity by making the CNs (or a CN-dependent function) essential.lld:pubmed
pubmed-article:7530227pubmed:languageenglld:pubmed
pubmed-article:7530227pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:citationSubsetIMlld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:7530227pubmed:statusMEDLINElld:pubmed
pubmed-article:7530227pubmed:monthDeclld:pubmed
pubmed-article:7530227pubmed:issn0378-1119lld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:JohnsonR KRKlld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:KoltinYYlld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:YoungP RPRlld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:McLaughlinM...lld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:MOIRJ BJBlld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:EngW KWKlld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:MorrisR ARAlld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:CafferkeyRRlld:pubmed
pubmed-article:7530227pubmed:authorpubmed-author:FaucetteLLlld:pubmed
pubmed-article:7530227pubmed:issnTypePrintlld:pubmed
pubmed-article:7530227pubmed:day30lld:pubmed
pubmed-article:7530227pubmed:volume151lld:pubmed
pubmed-article:7530227pubmed:geneSymbolFKS1lld:pubmed
pubmed-article:7530227pubmed:ownerNLMlld:pubmed
pubmed-article:7530227pubmed:authorsCompleteYlld:pubmed
pubmed-article:7530227pubmed:pagination61-71lld:pubmed
pubmed-article:7530227pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:meshHeadingpubmed-meshheading:7530227-...lld:pubmed
pubmed-article:7530227pubmed:year1994lld:pubmed
pubmed-article:7530227pubmed:articleTitleThe yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.lld:pubmed
pubmed-article:7530227pubmed:affiliationDepartment of Biomolecular Disovery, SmithKline Beecham Pharmaceuticals King of Prussia, PA 19406.lld:pubmed
pubmed-article:7530227pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7530227pubmed:publicationTypeComparative Studylld:pubmed
entrez-gene:851153entrezgene:pubmedpubmed-article:7530227lld:entrezgene
entrez-gene:853644entrezgene:pubmedpubmed-article:7530227lld:entrezgene
entrez-gene:854946entrezgene:pubmedpubmed-article:7530227lld:entrezgene
entrez-gene:851055entrezgene:pubmedpubmed-article:7530227lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:7530227lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:7530227lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:7530227lld:pubmed
More...