| pubmed-article:7524975 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C0553580 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C0348026 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C0086345 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C1515713 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C1522609 | lld:lifeskim |
| pubmed-article:7524975 | lifeskim:mentions | umls-concept:C1554112 | lld:lifeskim |
| pubmed-article:7524975 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7524975 | pubmed:dateCreated | 1994-11-28 | lld:pubmed |
| pubmed-article:7524975 | pubmed:abstractText | One consistent feature of the Ewing's tumour family is the presence of a balanced translocation involving band q12 and band q24 of chromosome 22 and chromosome 11. Recent cloning of the chromosome breakpoint regions of t(11;22)(q24;q12) Ewing's sarcoma translocation has revealed that the breakpoints were localized within the Ewing's sarcoma gene (EWS gene) on chromosome 22 and the Fli-1 gene on chromosome 11. Molecular genetic techniques can thus be applied to the detection of the t(11;22) translocation in Ewing's tumours. By reverse transcription and polymerase chain reaction technique (RT-PCR) 11 Ewing's tumour derived cell lines, 12 primary Ewing's tumours, and 11 tumours after treatment were analysed for the occurence of the t(11;22) translocation. Furthermore, blood and bone marrow samples from 5 patients were available for RT-PCR. In 78% of the cell lines and 91% of the primary Ewing's tumours the t(11;22) translocation was detectable by RT-PCR. In bone marrow samples from a Ewing's sarcoma patient presenting in relapse tumour cells were detected by molecular genetic analysis. Our results indicate that molecular genetic detection of the t(11;22) translocation is valuable in the differential diagnosis of small round cell tumours and will provide important information for the staging and prognosis of Ewing's tumour. | lld:pubmed |
| pubmed-article:7524975 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7524975 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7524975 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7524975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7524975 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7524975 | pubmed:issn | 0945-6317 | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:WinkelmannWW | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:BöckerWW | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:van ValenFF | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:JürgensHH | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:BurdachSS | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:BlasiusSS | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:StrehlSS | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:Dockhorn-Dwor... | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:SchäferK LKL | lld:pubmed |
| pubmed-article:7524975 | pubmed:author | pubmed-author:DantchevaRR | lld:pubmed |
| pubmed-article:7524975 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7524975 | pubmed:volume | 425 | lld:pubmed |
| pubmed-article:7524975 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7524975 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7524975 | pubmed:pagination | 107-12 | lld:pubmed |
| pubmed-article:7524975 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:meshHeading | pubmed-meshheading:7524975-... | lld:pubmed |
| pubmed-article:7524975 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7524975 | pubmed:articleTitle | Diagnostic value of the molecular genetic detection of the t(11;22) translocation in Ewing's tumours. | lld:pubmed |
| pubmed-article:7524975 | pubmed:affiliation | Gerhard Domagk Institute of Pathology, Westfälische Wilhelms-University, Münster, Germany. | lld:pubmed |
| pubmed-article:7524975 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7524975 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7524975 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7524975 | lld:pubmed |
