| pubmed-article:7522509 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7522509 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7522509 | lifeskim:mentions | umls-concept:C1522449 | lld:lifeskim |
| pubmed-article:7522509 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:7522509 | lifeskim:mentions | umls-concept:C1522302 | lld:lifeskim |
| pubmed-article:7522509 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:7522509 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7522509 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:7522509 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7522509 | pubmed:dateCreated | 1994-11-8 | lld:pubmed |
| pubmed-article:7522509 | pubmed:abstractText | Murine fibrosarcoma cells (SSK) exhibit a transient cisplatin resistance after low-dose irradiation (5 x 2 Gy) in vitro and in vivo. When resistance is lost, it can be restored by a single drug exposure which, without preirradiation, does not generate cisplatin resistance in parental cells. There is no cross-resistance to radiation. Metallothioneins, which are associated with cisplatin resistance after high-dose irradiation (15 x 6 Gy), do not correlate with induction and loss of cisplatin resistance after low-dose irradiation. Since cisplatin survival curves are also monotonous when drug resistance diminishes, an adaptive response is more likely than a mutational event to underlie cisplatin-induced resistance. Drug resistance can be overcome by combined exposure to cisplatin in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). Under these conditions, cisplatin sensitivity is increased 2.4- to 2.8-fold in the resistant strains compared with only 1.5- to 1.8-fold in the parental cells. The cellular platinum content with and without IBMX treatment is not significantly different in sensitive and resistant cells. Loss of drug resistance correlates with a decrease in cisplatin sensitisation by IBMX. This suggests that cisplatin resistance after low-dose irradiation may be associated with alterations of the cAMP-dependent signal transduction pathway. | lld:pubmed |
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| pubmed-article:7522509 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7522509 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7522509 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7522509 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7522509 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7522509 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:7522509 | pubmed:author | pubmed-author:Eichholtz-Wir... | lld:pubmed |
| pubmed-article:7522509 | pubmed:author | pubmed-author:HietelBB | lld:pubmed |
| pubmed-article:7522509 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7522509 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:7522509 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7522509 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7522509 | pubmed:pagination | 579-84 | lld:pubmed |
| pubmed-article:7522509 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7522509 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7522509 | pubmed:articleTitle | Cisplatin resistance in mouse fibrosarcoma cells after low-dose irradiation in vitro and in vivo. | lld:pubmed |
| pubmed-article:7522509 | pubmed:affiliation | GSF-Institut für Strahlenbiologie, Neuherberg, Germany. | lld:pubmed |
| pubmed-article:7522509 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7522509 | pubmed:publicationType | Comparative Study | lld:pubmed |
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