| pubmed-article:7520772 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7520772 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:7520772 | lifeskim:mentions | umls-concept:C0143630 | lld:lifeskim |
| pubmed-article:7520772 | lifeskim:mentions | umls-concept:C0525006 | lld:lifeskim |
| pubmed-article:7520772 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7520772 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:7520772 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7520772 | pubmed:dateCreated | 1994-9-28 | lld:pubmed |
| pubmed-article:7520772 | pubmed:abstractText | Interleukin-7 (IL-7) has been shown to be a critical factor in murine lymphoid development. It stimulates pre-B cells to divide in the absence of stroma cells and it is an important growth regulator of immature and mature T cells. IL-7 has been shown to synergize with stem cell factor (SCF) to provide a potent growth stimulus for pre-B cells. However, the combined effects of IL-7 and SCF on murine primitive hematopoietic cells in vitro have not been established. In the present study, the effects of recombinant rat (rr) SCF and recombinant human (rh) IL-7 on primitive murine bone marrow progenitors (Lin-Sca1+) were investigated in single-cell cloning experiments. rhIL-7 alone had no proliferative effect on Lin-Sca1+ cells, but in a dose-dependent manner directly enhanced rrSCF-induced colony formation, with an average increase in colony numbers of 2.7-fold. Interestingly, the cells formed in response to SCF and IL-7 were predominantly mature granulocytes. Thus, SCF and IL-7 synergize to stimulate early myelopoiesis in vitro. | lld:pubmed |
| pubmed-article:7520772 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7520772 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7520772 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7520772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7520772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7520772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7520772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7520772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7520772 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7520772 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7520772 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7520772 | pubmed:author | pubmed-author:BlomhoffH KHK | lld:pubmed |
| pubmed-article:7520772 | pubmed:author | pubmed-author:JacobsenS ESE | lld:pubmed |
| pubmed-article:7520772 | pubmed:author | pubmed-author:McNieceI KIK | lld:pubmed |
| pubmed-article:7520772 | pubmed:author | pubmed-author:VeibyO POP | lld:pubmed |
| pubmed-article:7520772 | pubmed:author | pubmed-author:FahlmanCC | lld:pubmed |
| pubmed-article:7520772 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7520772 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7520772 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:7520772 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7520772 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7520772 | pubmed:pagination | 1450-6 | lld:pubmed |
| pubmed-article:7520772 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7520772 | pubmed:meshHeading | pubmed-meshheading:7520772-... | lld:pubmed |
| pubmed-article:7520772 | pubmed:meshHeading | pubmed-meshheading:7520772-... | lld:pubmed |
| pubmed-article:7520772 | pubmed:meshHeading | pubmed-meshheading:7520772-... | lld:pubmed |
| pubmed-article:7520772 | pubmed:meshHeading | pubmed-meshheading:7520772-... | lld:pubmed |
| pubmed-article:7520772 | pubmed:meshHeading | pubmed-meshheading:7520772-... | lld:pubmed |
| pubmed-article:7520772 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7520772 | pubmed:articleTitle | Stem cell factor and interleukin-7 synergize to enhance early myelopoiesis in vitro. | lld:pubmed |
| pubmed-article:7520772 | pubmed:affiliation | Department of Immunology, Norwegian Radiumhospital, Oslo. | lld:pubmed |
| pubmed-article:7520772 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7520772 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7520772 | lld:pubmed |
