| pubmed-article:7517557 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7517557 | lifeskim:mentions | umls-concept:C0051300 | lld:lifeskim |
| pubmed-article:7517557 | lifeskim:mentions | umls-concept:C0164707 | lld:lifeskim |
| pubmed-article:7517557 | lifeskim:mentions | umls-concept:C1523935 | lld:lifeskim |
| pubmed-article:7517557 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:7517557 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:7517557 | pubmed:dateCreated | 1994-8-1 | lld:pubmed |
| pubmed-article:7517557 | pubmed:abstractText | The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) is a cell-surface glycoprotein of 4525 amino acids that functions as a hepatic endocytosis receptor for several plasma proteins. These include alpha 2-macroglobulin-protease complexes, free plasminogen activators as well as plasminogen activators complexed with their inhibitors, and beta-migrating very low density lipoproteins complexed with either apolipoprotein E or lipoprotein lipase. In the current study we used human and rat hepatoma cell lines to demonstrate that LRP can mediate the degradation of tissue factor pathway inhibitor (TFPI), a Kunitz-type plasma serine protease inhibitor that regulates tissue factor-induced blood coagulation. The cellular degradation of 125I-labeled TFPI (125I-TFPI) was inhibited more than 80% both by antibodies directed against LRP and by the LRP-associated 39-kDa protein, a protein that inhibits the binding and/or cell-mediated degradation of all ligands by LRP. Using rat hepatoma cells, we report that at 4 degrees C, 125I-TFPI binds to approximately 2 x 10(6) sites per cell with an equilibrium dissociation constant of approximately 30 nM. 125I-TFPI binding to the cell surface is not inhibited by the 39-kDa protein. Taken together, our results suggest that TFPI binds to an as-yet-unidentified cell surface molecule. After binding, LRP mediates the cellular degradation of TFPI. | lld:pubmed |
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| pubmed-article:7517557 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7517557 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7517557 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7517557 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7517557 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7517557 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7517557 | pubmed:author | pubmed-author:SchwartzA LAL | lld:pubmed |
| pubmed-article:7517557 | pubmed:author | pubmed-author:BrozeG JGJJr | lld:pubmed |
| pubmed-article:7517557 | pubmed:author | pubmed-author:WarshawskyII | lld:pubmed |
| pubmed-article:7517557 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7517557 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:7517557 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:7517557 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7517557 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7517557 | pubmed:pagination | 6664-8 | lld:pubmed |
| pubmed-article:7517557 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:7517557 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7517557 | pubmed:articleTitle | The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor. | lld:pubmed |
| pubmed-article:7517557 | pubmed:affiliation | Edward Mallinckrodt Department of Pediatrics, Jewish Hospital at Washington University School of Medicine, St. Louis, MO 63110. | lld:pubmed |
