| pubmed-article:7517449 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7517449 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7517449 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7517449 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:7517449 | lifeskim:mentions | umls-concept:C0752247 | lld:lifeskim |
| pubmed-article:7517449 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7517449 | pubmed:dateCreated | 1994-7-29 | lld:pubmed |
| pubmed-article:7517449 | pubmed:abstractText | 1. The high threshold, voltage-activated (HVA) calcium current was recorded from acutely isolated rat neocortical pyramidal neurones using the whole-cell patch technique to examine the effect of agents that block P-type calcium channels and to compare their effects to those of omega-conotoxin GVIA (omega-CgTX) and nifedipine. 2. When applied at a saturating concentration (100 nM) the peptide toxins omega-Aga-IVA and synthetic omega-Aga-IVA blocked 31.5 and 33.0% of the HVA current respectively. 3. A saturating concentration of nifedipine (10 microM) inhibited 48.2% of the omega-Aga-IVA-sensitive current, whereas saturating concentrations of both omega-Aga-IVA (100 nM) and omega-CgTX (10 microM) blocked separate specific components of the HVA current. 4. Partially purified funnel web spider toxin (FTX) at a dilution of 1:1000 blocked 81.4% of the HVA current and occluded the inhibitory effect of omega-Aga-IVA. Synthetic FTX 3.3 arginine polyamine (sFTX) at a concentration of 1 mM blocked 61.2% of the HVA current rapidly and reversibly. The effects of sFTX were partially occluded by pre-application of omega-Aga-IVA. We conclude that neither FTX nor sFTX blocked a specific component of the HVA current in these cells. 5. In view of the specificity of omega-Aga-IVA for P-type calcium channels in other preparations and for a specific component of the HVA current in dissociated neocortical neurones we conclude that about 30% of the HVA current in these neurones flow through P-channels. | lld:pubmed |
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| pubmed-article:7517449 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7517449 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7517449 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7517449 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7517449 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7517449 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:7517449 | pubmed:author | pubmed-author:BrownA MAM | lld:pubmed |
| pubmed-article:7517449 | pubmed:author | pubmed-author:CrillW EWE | lld:pubmed |
| pubmed-article:7517449 | pubmed:author | pubmed-author:SchwindtP CPC | lld:pubmed |
| pubmed-article:7517449 | pubmed:author | pubmed-author:SayerR JRJ | lld:pubmed |
| pubmed-article:7517449 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7517449 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7517449 | pubmed:volume | 475 | lld:pubmed |
| pubmed-article:7517449 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7517449 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7517449 | pubmed:pagination | 197-205 | lld:pubmed |
| pubmed-article:7517449 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7517449 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7517449 | pubmed:articleTitle | P-type calcium channels in rat neocortical neurones. | lld:pubmed |
| pubmed-article:7517449 | pubmed:affiliation | Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195. | lld:pubmed |
| pubmed-article:7517449 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7517449 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7517449 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7517449 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7517449 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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