| pubmed-article:7514607 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7514607 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:7514607 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:7514607 | lifeskim:mentions | umls-concept:C0032200 | lld:lifeskim |
| pubmed-article:7514607 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7514607 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:7514607 | lifeskim:mentions | umls-concept:C0246681 | lld:lifeskim |
| pubmed-article:7514607 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7514607 | pubmed:dateCreated | 1994-6-22 | lld:pubmed |
| pubmed-article:7514607 | pubmed:abstractText | To delineate potential angiogenic roles of platelet-derived growth factor (PDGF), we have investigated PDGF and its receptors on bovine aortic endothelial cells that exhibit spontaneous angiogenesis in vitro (angiogenic endothelial cells). Initiation of cord/tube formation by angiogenic endothelial cells required bovine or human serum. Neutralization of PDGF-BB in human serum with a monoclonal anti-PDGF-BB antibody reduced cord/tube formation by 37 +/- 10%, whereas neutralizing anti-PDGF-AA and an IgG isotype-matched control antibody had no effect. DNA synthesis in response to PDGF-BB increased as the cords and tubes developed; furthermore, PDGF-BB induced the incorporation of BrdU in the nuclei of cells associated with these structures. PDGF beta-receptor (PDGF-beta) mRNA increased concomitantly with cord/tube formation, and PDGFR-beta were specifically localized by immunocytochemistry to developing and mature cords and tubes. However, PDGFR-beta transcripts and protein were undetectable in nonangiogenic endothelial cells, and PDGF alpha-receptor mRNA was not expressed in either endothelial cell strain. In contrast to nonangiogenic endothelial cells, angiogenic endothelial cells did not express the PDGF B-chain, the required ligand for the PDGFR-beta. We conclude that (a) PDGF-BB can contribute to angiogenesis in vitro, (b) PDGFR-beta are specific for cord/tube-forming endothelial cells and mediate endothelial proliferation and cord/tube formation, and (c) in angiogenic and nonangiogenic endothelial cells, the expression of PDGFR-beta and PDGF B-chain is inversely correlated. We therefore suggest that paracrine PDGF might amplify angiogenesis via direct action on endothelially expressed PDGFR-beta. | lld:pubmed |
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| pubmed-article:7514607 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7514607 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7514607 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7514607 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7514607 | pubmed:month | May | lld:pubmed |
| pubmed-article:7514607 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:7514607 | pubmed:author | pubmed-author:RuppJJ | lld:pubmed |
| pubmed-article:7514607 | pubmed:author | pubmed-author:PechMM | lld:pubmed |
| pubmed-article:7514607 | pubmed:author | pubmed-author:SageE HEH | lld:pubmed |
| pubmed-article:7514607 | pubmed:author | pubmed-author:Iruela-Arispe... | lld:pubmed |
| pubmed-article:7514607 | pubmed:author | pubmed-author:BattegayE JEJ | lld:pubmed |
| pubmed-article:7514607 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7514607 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:7514607 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7514607 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7514607 | pubmed:pagination | 917-28 | lld:pubmed |
| pubmed-article:7514607 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7514607 | pubmed:meshHeading | pubmed-meshheading:7514607-... | lld:pubmed |
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| pubmed-article:7514607 | pubmed:meshHeading | pubmed-meshheading:7514607-... | lld:pubmed |
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| pubmed-article:7514607 | pubmed:meshHeading | pubmed-meshheading:7514607-... | lld:pubmed |
| pubmed-article:7514607 | pubmed:meshHeading | pubmed-meshheading:7514607-... | lld:pubmed |
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| pubmed-article:7514607 | pubmed:meshHeading | pubmed-meshheading:7514607-... | lld:pubmed |
| pubmed-article:7514607 | pubmed:meshHeading | pubmed-meshheading:7514607-... | lld:pubmed |
| pubmed-article:7514607 | pubmed:meshHeading | pubmed-meshheading:7514607-... | lld:pubmed |
| pubmed-article:7514607 | pubmed:meshHeading | pubmed-meshheading:7514607-... | lld:pubmed |
| pubmed-article:7514607 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7514607 | pubmed:articleTitle | PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. | lld:pubmed |
| pubmed-article:7514607 | pubmed:affiliation | Department of Research and Internal Medicine, University Hospital Basel, Switzerland. | lld:pubmed |
| pubmed-article:7514607 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7514607 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7514607 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
