| pubmed-article:7511643 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C0054961 | lld:lifeskim |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C0034788 | lld:lifeskim |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C0085536 | lld:lifeskim |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C1149880 | lld:lifeskim |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:7511643 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7511643 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7511643 | pubmed:dateCreated | 1994-4-29 | lld:pubmed |
| pubmed-article:7511643 | pubmed:abstractText | Cross-linking of the Ag receptor (AgR) induces intracellular signaling events in B cells, such as p21ras activation, that lead to their proliferation and differentiation. This event is accompanied by the tyrosine phosphorylation of the p21ras-associated GTPase-activating protein p120 ras.GAP, raising the possibility that AgR-stimulated p21ras activity is regulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases) in B cells. To test this possibility, we examined the effects of PTK and PTPase inhibitors on protein tyrosine phosphorylation and p21ras activation induced by AgR cross-linking in TNP-specific TA3 7.9 murine B lymphoma cells. Although AgR-induced protein tyrosine phosphorylation was inhibited by the PTK inhibitors genistein and herbimycin A, it was enhanced by exposure to the PTPase inhibitor phenylarsine oxide (PAO). Cross-linking of the AgR by Ag or F(ab')2 anti-IgM induced a rapid (within 5 min) two- to threefold increase in p21ras activation in 7.9 B cells. Interestingly, a second peak of p21ras activation was evident at approximately 40 min after stimulation. Genistein and herbimycin A and PAO each blocked AgR-stimulated p21ras activation. Similarly, Ag-induced p21ras activation was inhibited by pretreatment of 7.9 B cells with an anti-CD45 mAb (detects the 220-kDa B cell isoform of CD45). Moreover, p21ras activation was induced by Ag and F(ab')2 anti-IgM in CD45+ but not CD45- J558L microns 3 B cells. These data indicate that p21ras activation induced by AgR cross-linking in B cells is regulated by both PTK and CD45 PTPase activities. | lld:pubmed |
| pubmed-article:7511643 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7511643 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7511643 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7511643 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7511643 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7511643 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7511643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7511643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7511643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7511643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7511643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7511643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7511643 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7511643 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7511643 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7511643 | pubmed:author | pubmed-author:DelovitchT... | lld:pubmed |
| pubmed-article:7511643 | pubmed:author | pubmed-author:CambierJ CJC | lld:pubmed |
| pubmed-article:7511643 | pubmed:author | pubmed-author:HarwoodAA | lld:pubmed |
| pubmed-article:7511643 | pubmed:author | pubmed-author:KawauchiKK | lld:pubmed |
| pubmed-article:7511643 | pubmed:author | pubmed-author:LazarusA HAH | lld:pubmed |
| pubmed-article:7511643 | pubmed:author | pubmed-author:RapoportM JMJ | lld:pubmed |
| pubmed-article:7511643 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7511643 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7511643 | pubmed:volume | 152 | lld:pubmed |
| pubmed-article:7511643 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7511643 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7511643 | pubmed:pagination | 3306-16 | lld:pubmed |
| pubmed-article:7511643 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7511643 | pubmed:meshHeading | pubmed-meshheading:7511643-... | lld:pubmed |
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| pubmed-article:7511643 | pubmed:meshHeading | pubmed-meshheading:7511643-... | lld:pubmed |
| pubmed-article:7511643 | pubmed:meshHeading | pubmed-meshheading:7511643-... | lld:pubmed |
| pubmed-article:7511643 | pubmed:meshHeading | pubmed-meshheading:7511643-... | lld:pubmed |
| pubmed-article:7511643 | pubmed:meshHeading | pubmed-meshheading:7511643-... | lld:pubmed |
| pubmed-article:7511643 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7511643 | pubmed:articleTitle | Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor. | lld:pubmed |
| pubmed-article:7511643 | pubmed:affiliation | Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:7511643 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7511643 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7511643 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7511643 | lld:pubmed |
