The point mutation Arg615-->Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia.

Source:http://linkedlifedata.com/resource/pubmed/id/7511586

J. Biol. Chem. 1994 Apr 1 269 13 9413-5

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7511586