pubmed-article:7510436 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C0376436 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C0872192 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
pubmed-article:7510436 | lifeskim:mentions | umls-concept:C0292133 | lld:lifeskim |
pubmed-article:7510436 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:7510436 | pubmed:dateCreated | 1994-4-14 | lld:pubmed |
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pubmed-article:7510436 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7510436 | pubmed:abstractText | To identify conserved humoral antigenic determinants within the hepatitis C virus (HCV) envelope protein E2, we expressed a peptide library containing random short fragments of the HCV envelope in yeast. Clones were identified using a monospecific rabbit antibody to a region downstream of the E2 hypervariable region. The clones define the limits of two original antigenic domains: a major one (aa 493-576) and a minor one (aa 535-606). The major antigenic domain maps in a region that displays a high degree of homology within a (HCV) subtype (92-97.6% identity). Yeast-encoded determinants were characterized by Western blot analysis, N-glycosidase F digestion, and using a panel of synthetic peptides. The data suggest that the major antigenic domain contains at least two determinants, one of them mimicked by an 18-mer peptide (aa 514-531). ELISA and competitive inhibition assays demonstrated that: (1) the determinants appear subtype 1a-specific, (2) seroprevalence of antibody to the determinants is rather low (20.6%), and (3) donors show a heterologous response to the different determinants. Antibody response to the E2 determinants was studied in HCV-infected chimpanzees and post-transfusion-associated NANB hepatitis cases. The antibody response was found during chronic infection and may not be effective for virus clearance. | lld:pubmed |
pubmed-article:7510436 | pubmed:language | eng | lld:pubmed |
pubmed-article:7510436 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7510436 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:7510436 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7510436 | pubmed:month | Apr | lld:pubmed |
pubmed-article:7510436 | pubmed:issn | 0042-6822 | lld:pubmed |
pubmed-article:7510436 | pubmed:author | pubmed-author:PrinceA MAM | lld:pubmed |
pubmed-article:7510436 | pubmed:author | pubmed-author:TiollaisPP | lld:pubmed |
pubmed-article:7510436 | pubmed:author | pubmed-author:InchauspeGG | lld:pubmed |
pubmed-article:7510436 | pubmed:author | pubmed-author:MadaulePP | lld:pubmed |
pubmed-article:7510436 | pubmed:author | pubmed-author:BenichouSS | lld:pubmed |
pubmed-article:7510436 | pubmed:author | pubmed-author:MimsM HMH | lld:pubmed |
pubmed-article:7510436 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7510436 | pubmed:volume | 200 | lld:pubmed |
pubmed-article:7510436 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7510436 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7510436 | pubmed:pagination | 246-55 | lld:pubmed |
pubmed-article:7510436 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:7510436 | pubmed:year | 1994 | lld:pubmed |
pubmed-article:7510436 | pubmed:articleTitle | Characterization and mapping of a B-cell immunogenic domain in hepatitis C virus E2 glycoprotein using a yeast peptide library. | lld:pubmed |
pubmed-article:7510436 | pubmed:affiliation | Laboratory of Virology and Parasitology, Lindsley F. Kimball Research Institute of the New York Blood Center, New York 10021. | lld:pubmed |
pubmed-article:7510436 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:7510436 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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