| pubmed-article:7508731 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7508731 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:7508731 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7508731 | lifeskim:mentions | umls-concept:C0935597 | lld:lifeskim |
| pubmed-article:7508731 | lifeskim:mentions | umls-concept:C0030580 | lld:lifeskim |
| pubmed-article:7508731 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:7508731 | lifeskim:mentions | umls-concept:C0016601 | lld:lifeskim |
| pubmed-article:7508731 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7508731 | lifeskim:mentions | umls-concept:C0031586 | lld:lifeskim |
| pubmed-article:7508731 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7508731 | pubmed:dateCreated | 1994-3-18 | lld:pubmed |
| pubmed-article:7508731 | pubmed:abstractText | Phorbol 12-myristate 13-acetate (TPA) augmented the effects of forskolin, and inhibited the effects of isoproterenol on cAMP accumulation in mouse parotid acini. Treatment of intact cells with the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (MIX), blocked TPA inhibition of isoproterenol but not forskolin-stimulated cAMP accumulation. TPA also caused the translocation of protein kinase C (PKC) from cytosol to membrane. Pre-treatment of parotid acini with TPA for 30 min enhanced the forskolin and isoproterenol-stimulated adenylate cyclase activity in isolated parotid membranes. Addition of purified PKC (pPKC) to parotid membranes mimicked the effects of TPA in increasing cAMP synthesis; the effects were blocked in the absence of calcium and phospholipid, and in the presence of the synthetic peptide (PKC 19-36). Purified PKC also mimicked the effects of TPA in augmenting forskolin and isoproterenol-stimulated adenylate cyclase activities in the cell-free system. Data suggest that the differential regulation of forskolin and isoproterenol-stimulated cAMP accumulation by TPA results from modification of enzymes that synthesize and degrade cAMP. | lld:pubmed |
| pubmed-article:7508731 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7508731 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7508731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7508731 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7508731 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7508731 | pubmed:issn | 0898-6568 | lld:pubmed |
| pubmed-article:7508731 | pubmed:author | pubmed-author:JacobsonKK | lld:pubmed |
| pubmed-article:7508731 | pubmed:author | pubmed-author:WatsonE LEL | lld:pubmed |
| pubmed-article:7508731 | pubmed:author | pubmed-author:MeierKK | lld:pubmed |
| pubmed-article:7508731 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7508731 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:7508731 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7508731 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7508731 | pubmed:pagination | 583-92 | lld:pubmed |
| pubmed-article:7508731 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
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| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:meshHeading | pubmed-meshheading:7508731-... | lld:pubmed |
| pubmed-article:7508731 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7508731 | pubmed:articleTitle | Phorbol ester has different effects on forskolin and beta-adrenergic-stimulated cAMP accumulation in mouse parotid acini. | lld:pubmed |
| pubmed-article:7508731 | pubmed:affiliation | Department of Oral Biology, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:7508731 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7508731 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7508731 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
