| pubmed-article:7507928 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C0041485 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C0443301 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C1709915 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:7507928 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:7507928 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7507928 | pubmed:dateCreated | 1994-3-4 | lld:pubmed |
| pubmed-article:7507928 | pubmed:abstractText | An aromatic residue, tyrosine 326 in the prototypical human beta 2-adrenergic receptor, exists in a highly conserved sequence motif in virtually all members of the G protein-coupled receptor family. The potential role of this conserved aromatic amino acid residue in the cellular processes of sequestration (a rapid internalization of the surface receptor) and down-regulation (a slower loss of total cellular receptors) associated with agonist-mediated desensitization of the beta 2-adrenergic receptor was assessed by replacing tyrosine residue 326 with an alanine residue (beta 2AR-Y326A). This mutation completely abolishes agonist-mediated receptor sequestration without affecting the ability of the receptor to activate maximally adenylyl cyclase, to undergo rapid desensitization, and to down-regulate in response to agonist. The only other major change associated with the mutated receptor is a complete loss of the ability to resensitize following rapid desensitization. These results imply that this tyrosine residue, which is part of a highly conserved sequence motif in G protein-coupled receptors, may be responsible for their agonist-mediated sequestration and that sequestration and down-regulation of the receptor are dissociable phenomena. The lack of resensitization in the sequestration-defective beta 2-adrenergic receptor mutant strongly suggests that the sequestration pathway is an important mechanism by which cells re-establish the normal responsiveness of G protein-coupled receptors following the removal of agonist. | lld:pubmed |
| pubmed-article:7507928 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7507928 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507928 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7507928 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7507928 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7507928 | pubmed:author | pubmed-author:LefkowitzR... | lld:pubmed |
| pubmed-article:7507928 | pubmed:author | pubmed-author:CaronM GMG | lld:pubmed |
| pubmed-article:7507928 | pubmed:author | pubmed-author:BarakL SLS | lld:pubmed |
| pubmed-article:7507928 | pubmed:author | pubmed-author:KwatraM MMM | lld:pubmed |
| pubmed-article:7507928 | pubmed:author | pubmed-author:TiberiMM | lld:pubmed |
| pubmed-article:7507928 | pubmed:author | pubmed-author:FreedmanN JNJ | lld:pubmed |
| pubmed-article:7507928 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7507928 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:7507928 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:7507928 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7507928 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7507928 | pubmed:pagination | 2790-5 | lld:pubmed |
| pubmed-article:7507928 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:meshHeading | pubmed-meshheading:7507928-... | lld:pubmed |
| pubmed-article:7507928 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7507928 | pubmed:articleTitle | A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. | lld:pubmed |
| pubmed-article:7507928 | pubmed:affiliation | Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina 27710. | lld:pubmed |
| pubmed-article:7507928 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7507928 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7507928 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7507928 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507928 | lld:pubmed |
