| pubmed-article:7507078 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C0439660 | lld:lifeskim |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C1334095 | lld:lifeskim |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C1953345 | lld:lifeskim |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C1520767 | lld:lifeskim |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C0123258 | lld:lifeskim |
| pubmed-article:7507078 | lifeskim:mentions | umls-concept:C0024779 | lld:lifeskim |
| pubmed-article:7507078 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7507078 | pubmed:dateCreated | 1994-2-22 | lld:pubmed |
| pubmed-article:7507078 | pubmed:abstractText | The gene for insulin-like growth factor-binding protein 4 (IGFBP4) codes for a serum protein that binds to the family of insulin-like growth factors and modulates their activity. It has been mapped by in situ hybridization to chromosome region 17q12-q21.1. We have developed a CA-repeat polymorphism from a cosmid clone containing IGFBP4. By linkage analysis, IGFBP4 maps to the chromosome 17q interval THRA1-D17S579. This interval also contains the gene for hereditary breast-ovarian cancer, BRCA1. Genetic recombination between IGFBP4 and BRCA1 places IGFBP4 centromeric to the cancer susceptibility gene and effectively excludes it as a candidate gene for BRCA1. IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015. IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1. | lld:pubmed |
| pubmed-article:7507078 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507078 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7507078 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507078 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7507078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7507078 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7507078 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7507078 | pubmed:issn | 0888-7543 | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:LenoirGG | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:FeunteunJJ | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:LynchHH | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:MorganKK | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:PollakMM | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:HuynhHH | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:EhrenborgEE | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:ToninPP | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:VivierAA | lld:pubmed |
| pubmed-article:7507078 | pubmed:author | pubmed-author:ZazzoBB | lld:pubmed |
| pubmed-article:7507078 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7507078 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:7507078 | pubmed:geneSymbol | IGFBP4 | lld:pubmed |
| pubmed-article:7507078 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7507078 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7507078 | pubmed:pagination | 414-7 | lld:pubmed |
| pubmed-article:7507078 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:meshHeading | pubmed-meshheading:7507078-... | lld:pubmed |
| pubmed-article:7507078 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7507078 | pubmed:articleTitle | The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer. | lld:pubmed |
| pubmed-article:7507078 | pubmed:affiliation | Department of Medicine, McGill University, Montreal, Canada. | lld:pubmed |
| pubmed-article:7507078 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7507078 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7507078 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3487 | entrezgene:pubmed | pubmed-article:7507078 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7507078 | lld:pubmed |
