Linked Life Data

7501232

Source:http://linkedlifedata.com/resource/pubmed/id/7501232

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pubmed-article:7501232pubmed:abstractTextThe effect of nicotinic receptor activation on intracellular calcium concentrations ([Ca2+]i) was quantitated in populations of cultured hippocampal neurons loaded with Fura-2. Nicotine (50 microM) and cytisine (50 microM) increased [Ca2+]i by 100%. This response was abolished in the presence of the nicotinic antagonist methyllycaconitine (MLA) whereas KCl-evoked increases in [Ca2+]i were insensitive to MLA. Glial cultures were unaffected by nicotine, although they did respond to glutamate with increased [Ca2+]i. In hippocampal neurons, responses to nicotinic agonists and KCl were dependent on the presence of extracellular Ca2+ and were similarly sensitive (85% inhibition) to CdCl2. These results are consistent with the presence of functional nicotinic receptors on hippocampal neurons. The receptors appear to elevate [Ca2+]i by promoting the influx of extracellular Ca2+ through voltage-gated calcium channels.lld:pubmed
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pubmed-article:7501232pubmed:articleTitleNicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels.lld:pubmed
pubmed-article:7501232pubmed:affiliationSchool of Biology and Biochemistry, University of Bath, UK.lld:pubmed
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