| pubmed-article:7498962 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7498962 | lifeskim:mentions | umls-concept:C0600534 | lld:lifeskim |
| pubmed-article:7498962 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:7498962 | lifeskim:mentions | umls-concept:C0132555 | lld:lifeskim |
| pubmed-article:7498962 | lifeskim:mentions | umls-concept:C0597298 | lld:lifeskim |
| pubmed-article:7498962 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7498962 | pubmed:issue | 6 Pt 2 | lld:pubmed |
| pubmed-article:7498962 | pubmed:dateCreated | 1996-1-16 | lld:pubmed |
| pubmed-article:7498962 | pubmed:abstractText | An abnormal L-arginine-nitric oxide axis has been suggested to be relevant to the genesis of salt-sensitive hypertension. In the present study we investigated the activities of three isoforms of nitric oxide synthase (NOS) in the kidney of Dahl salt-sensitive and salt-resistant rats. Five-week-old Dahl Iwai salt-sensitive (n = 9) and salt-resistant (n = 10) rats were maintained on a high salt diet (4% sodium chloride) for 4 weeks. We measured calcium-dependent and calcium-independent NOS activities in each particulate and soluble fraction of kidney by conversion of L-[3H]arginine to L-[3H]citrulline. Systolic blood pressure was elevated significantly (P < .001) in salt-sensitive but not salt-resistant rats. Calcium-dependent NOS activity in the soluble fraction was significantly lower in salt-sensitive rats than in salt-resistant rats (25.8 +/- 9.0 versus 48.2 +/- 19.2 disintegrations per microgram protein, respectively; P < .01). There were no differences in calcium-dependent NOS activity in the particulate fraction and calcium-independent NOS activity in the soluble fraction between groups. Renal norepinephrine content was lower in salt-sensitive rats than in salt-resistant rats (P < .05) and was positively correlated with calcium-dependent NOS activity in the soluble fraction (P < .01). Although no differences in endothelial and inducible-type NOS activity were observed a significant reduction in calcium-dependent NOS activity in the soluble fraction of the kidney of salt-sensitive rats suggests that the decreased neural-type NOS activity may in part be involved in the mechanism of salt-sensitive hypertension, possibly through alterations in renal sympathetic nervous activity and sodium handling. | lld:pubmed |
| pubmed-article:7498962 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7498962 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7498962 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7498962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7498962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7498962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7498962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7498962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7498962 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7498962 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7498962 | pubmed:issn | 0194-911X | lld:pubmed |
| pubmed-article:7498962 | pubmed:author | pubmed-author:SaitoKK | lld:pubmed |
| pubmed-article:7498962 | pubmed:author | pubmed-author:CHUS YSY | lld:pubmed |
| pubmed-article:7498962 | pubmed:author | pubmed-author:IkedaYY | lld:pubmed |
| pubmed-article:7498962 | pubmed:author | pubmed-author:YokoyamaMM | lld:pubmed |
| pubmed-article:7498962 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7498962 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:7498962 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7498962 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7498962 | pubmed:pagination | 1030-4 | lld:pubmed |
| pubmed-article:7498962 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7498962 | pubmed:meshHeading | pubmed-meshheading:7498962-... | lld:pubmed |
| pubmed-article:7498962 | pubmed:meshHeading | pubmed-meshheading:7498962-... | lld:pubmed |
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| pubmed-article:7498962 | pubmed:meshHeading | pubmed-meshheading:7498962-... | lld:pubmed |
| pubmed-article:7498962 | pubmed:meshHeading | pubmed-meshheading:7498962-... | lld:pubmed |
| pubmed-article:7498962 | pubmed:meshHeading | pubmed-meshheading:7498962-... | lld:pubmed |
| pubmed-article:7498962 | pubmed:meshHeading | pubmed-meshheading:7498962-... | lld:pubmed |
| pubmed-article:7498962 | pubmed:meshHeading | pubmed-meshheading:7498962-... | lld:pubmed |
| pubmed-article:7498962 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7498962 | pubmed:articleTitle | Nitric oxide synthase isoform activities in kidney of Dahl salt-sensitive rats. | lld:pubmed |
| pubmed-article:7498962 | pubmed:affiliation | First Department of Internal Medicine, Kobe University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:7498962 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7498962 | pubmed:publicationType | Comparative Study | lld:pubmed |
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