| pubmed-article:7497909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7497909 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:7497909 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:7497909 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:7497909 | lifeskim:mentions | umls-concept:C0086154 | lld:lifeskim |
| pubmed-article:7497909 | lifeskim:mentions | umls-concept:C0599918 | lld:lifeskim |
| pubmed-article:7497909 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:7497909 | pubmed:dateCreated | 1996-1-18 | lld:pubmed |
| pubmed-article:7497909 | pubmed:abstractText | This investigation elucidates the role of antioxidant system in cisplatin induced nephrotoxicity and the nephroprotection with diethyldithiocarbamate (DDTC). Male Wistar rats were injected with 1) cisplatin; 2) cisplatin+DDTC and 3) vehicle control. Rats were sacrificed three days post-treatment and the corticomedullary junction of the kidney was isolated adn were analyzed for GSH, GSSG, SOD, CAT, and GSH.Px. Serum creatinine increased (500% of control) following cisplatin administration which decreased to 200% of control with DDTC. Cisplatin treated rats showed depletion of GSH levels, while cisplatin+DDTC injected rats had GSH values similar to controls. SOD and GSH.Px activities were found to be 63 and 40% of control following cisplatin administration which increased to 109 and 75% of control with DDTC respectively. Our findings suggest that cisplatin nephrotoxicity is mediated by impaired activities of SOD and GSH-Px enzymes and by GSH depletion. The protective mechanism of DDTC against cisplatin nephrotoxicity is related to the prevention of GSH depletion and restoring SOD and GSH-Px activities in the kidney of rats. | lld:pubmed |
| pubmed-article:7497909 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7497909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7497909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7497909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7497909 | pubmed:issn | 0148-0545 | lld:pubmed |
| pubmed-article:7497909 | pubmed:author | pubmed-author:SomaniS MSM | lld:pubmed |
| pubmed-article:7497909 | pubmed:author | pubmed-author:RybakL PLP | lld:pubmed |
| pubmed-article:7497909 | pubmed:author | pubmed-author:RaviRR | lld:pubmed |
| pubmed-article:7497909 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7497909 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:7497909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7497909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7497909 | pubmed:pagination | 151-70 | lld:pubmed |
| pubmed-article:7497909 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7497909 | pubmed:meshHeading | pubmed-meshheading:7497909-... | lld:pubmed |
| pubmed-article:7497909 | pubmed:meshHeading | pubmed-meshheading:7497909-... | lld:pubmed |
| pubmed-article:7497909 | pubmed:meshHeading | pubmed-meshheading:7497909-... | lld:pubmed |
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| pubmed-article:7497909 | pubmed:meshHeading | pubmed-meshheading:7497909-... | lld:pubmed |
| pubmed-article:7497909 | pubmed:articleTitle | Diethyldithiocarbamate protection against cisplatin nephrotoxicity: antioxidant system. | lld:pubmed |
| pubmed-article:7497909 | pubmed:affiliation | Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield, USA. | lld:pubmed |
| pubmed-article:7497909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7497909 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7497909 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
