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pubmed-article:7496909pubmed:abstractTextAlzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients < 6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.lld:pubmed
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pubmed-article:7496909pubmed:articleTitleTransforming growth factor beta in Alzheimer's disease.lld:pubmed
pubmed-article:7496909pubmed:affiliationNeuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, MN 55404, USA.lld:pubmed
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pubmed-article:7496909pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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