| pubmed-article:7496335 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7496335 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7496335 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7496335 | lifeskim:mentions | umls-concept:C0339543 | lld:lifeskim |
| pubmed-article:7496335 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:7496335 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:7496335 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7496335 | pubmed:dateCreated | 1996-1-16 | lld:pubmed |
| pubmed-article:7496335 | pubmed:abstractText | Insulin-like growth factor I (IGF-I) is thought to play a role in the development of proliferative diabetic retinopathy. Proliferative diabetic retinopathy is characterised by the formation of fibrovascular epiretinal membranes, and IGF-I may initiate and/or potentiate this epiretinal proliferation. To evaluate further the part played by IGF-I in the development of epiretinal tissue, we investigated the presence of IGF-I receptor/binding protein in proliferating diabetic fibrovascular epiretinal membranes. Five fibrovascular epiretinal membranes were obtained by vitrectomy from five patients with proliferating diabetic retinopathy. The presence of IGF-I receptors was investigated by autoradiography using 125I-labeled IGF-I on frozen sections. To characterise binding specificity, some sections were preincubated with either insulin or unlabeled IGF-I. Sections of post-mortem liver were used as controls. Strong labeling of cells with 125I-labeled IGF-I was observed in all epiretinal membranes and in liver cells. Almost no autoradiographic labeling was observed in sections that had been blocked with non-radioactive IGF-I, and very little labeling was found following blockage with insulin. Our preliminary study suggests the presence of IGF-I receptor/binding protein in human diabetic epiretinal membranes. These results support the hypothesis that IGF-I may be involved in the formation of proliferative diabetic membranes. | lld:pubmed |
| pubmed-article:7496335 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7496335 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7496335 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7496335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7496335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7496335 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7496335 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7496335 | pubmed:issn | 0941-2921 | lld:pubmed |
| pubmed-article:7496335 | pubmed:author | pubmed-author:CarterN DND | lld:pubmed |
| pubmed-article:7496335 | pubmed:author | pubmed-author:HiscottPP | lld:pubmed |
| pubmed-article:7496335 | pubmed:author | pubmed-author:AtionuAA | lld:pubmed |
| pubmed-article:7496335 | pubmed:author | pubmed-author:GregorZ JZJ | lld:pubmed |
| pubmed-article:7496335 | pubmed:author | pubmed-author:UlbigM WMW | lld:pubmed |
| pubmed-article:7496335 | pubmed:author | pubmed-author:Wolfensberger... | lld:pubmed |
| pubmed-article:7496335 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7496335 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:7496335 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7496335 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7496335 | pubmed:pagination | 264-8 | lld:pubmed |
| pubmed-article:7496335 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:meshHeading | pubmed-meshheading:7496335-... | lld:pubmed |
| pubmed-article:7496335 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7496335 | pubmed:articleTitle | Insulin-like growth factor I (IGF-I) receptor/binding protein in human diabetic epiretinal membranes. | lld:pubmed |
| pubmed-article:7496335 | pubmed:affiliation | Moorfields Eye Hospital, Vitreo-Retinal Department, London, UK. | lld:pubmed |
| pubmed-article:7496335 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7496335 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
