| pubmed-article:7492762 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7492762 | lifeskim:mentions | umls-concept:C0023493 | lld:lifeskim |
| pubmed-article:7492762 | lifeskim:mentions | umls-concept:C0663182 | lld:lifeskim |
| pubmed-article:7492762 | lifeskim:mentions | umls-concept:C0085101 | lld:lifeskim |
| pubmed-article:7492762 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7492762 | pubmed:dateCreated | 1996-1-11 | lld:pubmed |
| pubmed-article:7492762 | pubmed:abstractText | Adult T-cell leukemia (ATL) is a malignancy of mature lymphocytes caused by the retrovirus human T-cell lymphotropic virus-I. It is an aggressive leukemia with a median survival time of 9 months; no chemotherapy regimen appears successful in inducing long-term disease-free survival. The scientific basis of the present study is that ATL cells express high-affinity interleukin-2 receptors identified by the anti-Tac monoclonal antibody, whereas normal resting cells do not. To exploit this difference, we administered anti-Tac armed with Yttrium-90 (90Y) to 18 patients with ATL initially (first 9 patients) in a phase I dose-escalation trial and subsequently (second group of 9 patients) in a phase II trial involving a uniform 10-mCi dose of 90Y-labeled anti-Tac. Patients undergoing a remission were permitted to receive up to eight additional doses. At the 5- to 15-mCi doses used, 9 of 16 evaluable patients responded to 90Y anti-Tac with a partial (7 patients) or complete (2 patients) remission. The responses observed represent improved efficacy in terms of length of remission when compared with previous results with unmodified anti-Tac. Clinically meaningful (> or = grade 3) toxicity was largely limited to the hematopoietic system. In conclusion, radioimmunotherapy with 90Y anti-Tac directed toward the IL-2R expressed on ATL cells may provide a useful approach for treatment of this aggressive malignancy. | lld:pubmed |
| pubmed-article:7492762 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492762 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7492762 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492762 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7492762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7492762 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7492762 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7492762 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:NelsonD LDL | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:WaldmannT ATA | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:EnglandRR | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:HanchardBB | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:WhiteJ DJD | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:JohnsonJ AJA | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:GoldmanC KCK | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:JaffeE SES | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:JunghansR PRP | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:FleisherT ATA | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:MannaSS | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:ReynoldsJ CJC | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:RoesslerEE | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:GansowO AOA | lld:pubmed |
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| pubmed-article:7492762 | pubmed:author | pubmed-author:PaikC HCH | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:BamfordRR | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:Kasten-Sporte... | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:LitouHH | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:TopL ELE | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:ZaknoenEE | lld:pubmed |
| pubmed-article:7492762 | pubmed:author | pubmed-author:Jackson-White... | lld:pubmed |
| pubmed-article:7492762 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7492762 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7492762 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:7492762 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7492762 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7492762 | pubmed:pagination | 4063-75 | lld:pubmed |
| pubmed-article:7492762 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7492762 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7492762 | pubmed:articleTitle | Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac. | lld:pubmed |
| pubmed-article:7492762 | pubmed:affiliation | Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:7492762 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7492762 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7492762 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| pubmed-article:7492762 | pubmed:publicationType | Clinical Trial, Phase I | lld:pubmed |
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