| pubmed-article:7491499 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7491499 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:7491499 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:7491499 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7491499 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:7491499 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:7491499 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:7491499 | pubmed:issue | 5241 | lld:pubmed |
| pubmed-article:7491499 | pubmed:dateCreated | 1996-1-4 | lld:pubmed |
| pubmed-article:7491499 | pubmed:abstractText | Intracellular calcium (Ca2+) inhibits the opening of L-type (alpha 1C) Ca2+ channels, providing physiological control of Ca2+ entry into a wide variety of cells. A structural determinant of this Ca(2+)-sensitive inactivation was revealed by chimeric Ca2+ channels derived from parental alpha 1C and alpha 1E channels, the latter of which is a neuronal channel lacking Ca2+ inactivation. A consensus Ca(2+)-binding motif (an EF hand), located on the alpha 1C subunit, was required for Ca2+ inactivation. Donation of the alpha 1C EF-hand region to the alpha 1E channel conferred the Ca(2+)-inactivating phenotype. These results strongly suggest that Ca2+ binding to the alpha 1C subunit initiates Ca2+ inactivation. | lld:pubmed |
| pubmed-article:7491499 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7491499 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7491499 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7491499 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7491499 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7491499 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7491499 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:7491499 | pubmed:author | pubmed-author:Perez-ReyesEE | lld:pubmed |
| pubmed-article:7491499 | pubmed:author | pubmed-author:WangYY | lld:pubmed |
| pubmed-article:7491499 | pubmed:author | pubmed-author:WeeTT | lld:pubmed |
| pubmed-article:7491499 | pubmed:author | pubmed-author:JonesLL | lld:pubmed |
| pubmed-article:7491499 | pubmed:author | pubmed-author:GutV AVA | lld:pubmed |
| pubmed-article:7491499 | pubmed:author | pubmed-author:SnutchT PTP | lld:pubmed |
| pubmed-article:7491499 | pubmed:author | pubmed-author:SomovV IVI | lld:pubmed |
| pubmed-article:7491499 | pubmed:author | pubmed-author:de LeonMM | lld:pubmed |
| pubmed-article:7491499 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7491499 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7491499 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7491499 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7491499 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7491499 | pubmed:pagination | 1502-6 | lld:pubmed |
| pubmed-article:7491499 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7491499 | pubmed:meshHeading | pubmed-meshheading:7491499-... | lld:pubmed |
| pubmed-article:7491499 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7491499 | pubmed:articleTitle | Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels. | lld:pubmed |
| pubmed-article:7491499 | pubmed:affiliation | Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. | lld:pubmed |
| pubmed-article:7491499 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7491499 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7491499 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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