| pubmed-article:7487877 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7487877 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7487877 | lifeskim:mentions | umls-concept:C0238421 | lld:lifeskim |
| pubmed-article:7487877 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7487877 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7487877 | pubmed:dateCreated | 1995-11-28 | lld:pubmed |
| pubmed-article:7487877 | pubmed:abstractText | Regulation of synthesis of the selenoenzymes cytosolic glutathione peroxidase (GSH-Px), phospholipid hydroperoxide glutathione peroxidase (PHGSH-Px) and type-1 iodothyronine 5'-deiodinase (5'IDI) was investigated in liver, thyroid and heart of rats fed on diets containing 0.405, 0.104 (Se-adequate), 0.052, 0.024 or 0.003 mg of Se/kg. Severe Se deficiency (0.003 mg of Se/kg) caused almost total loss of GSH-Px activity and mRNA in liver and heart. 5'IDI activity decreased by 95% in liver and its mRNA by 50%; in the thyroid, activity increased by 15% and mRNA by 95%. PHGSH-Px activity was reduced by 75% in the liver and 60% in the heart but mRNA levels were unchanged; in the thyroid, PHGSH-Px activity was unaffected by Se depletion but its mRNA increased by 52%. Thus there is differential regulation of the three mRNAs and subsequent protein synthesis within and between organs, suggesting both that mechanisms exist to channel Se for synthesis of a particular enzyme and that there is tissue-specific regulation of selenoenzyme mRNAs. During Se depletion, the levels of selenoenzyme mRNA did not necessarily parallel the changes in enzyme activity, suggesting a distinct mechanism for regulating mRNA levels. Nuclear run-off assays with isolated liver nuclei showed severe Se deficiency to have no effect on transcription of the three genes, suggesting that there is post-transcriptional control of the three selenoenzymes, probably involving regulation of mRNA stability. | lld:pubmed |
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| pubmed-article:7487877 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7487877 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7487877 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7487877 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7487877 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:7487877 | pubmed:author | pubmed-author:HeskethJ EJE | lld:pubmed |
| pubmed-article:7487877 | pubmed:author | pubmed-author:BeckettG JGJ | lld:pubmed |
| pubmed-article:7487877 | pubmed:author | pubmed-author:NicotNN | lld:pubmed |
| pubmed-article:7487877 | pubmed:author | pubmed-author:ArthurJ RJR | lld:pubmed |
| pubmed-article:7487877 | pubmed:author | pubmed-author:DyerJ AJA | lld:pubmed |
| pubmed-article:7487877 | pubmed:author | pubmed-author:SundeR ARA | lld:pubmed |
| pubmed-article:7487877 | pubmed:author | pubmed-author:BermanoGG | lld:pubmed |
| pubmed-article:7487877 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7487877 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7487877 | pubmed:volume | 311 ( Pt 2) | lld:pubmed |
| pubmed-article:7487877 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7487877 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7487877 | pubmed:pagination | 425-30 | lld:pubmed |
| pubmed-article:7487877 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7487877 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7487877 | pubmed:articleTitle | Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats. | lld:pubmed |
| pubmed-article:7487877 | pubmed:affiliation | Rowett Research Institute, Bucksburn, Aberdeen, Scotland, U.K. | lld:pubmed |
| pubmed-article:7487877 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7487877 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7487877 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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