| pubmed-article:7484159 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7484159 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:7484159 | lifeskim:mentions | umls-concept:C0026032 | lld:lifeskim |
| pubmed-article:7484159 | lifeskim:mentions | umls-concept:C0017237 | lld:lifeskim |
| pubmed-article:7484159 | lifeskim:mentions | umls-concept:C0026259 | lld:lifeskim |
| pubmed-article:7484159 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:7484159 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7484159 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7484159 | pubmed:dateCreated | 1995-11-30 | lld:pubmed |
| pubmed-article:7484159 | pubmed:abstractText | Lung targeting gelatin microspheres of mitoxantrone (DHAQ) were prepared by a two-step method. The diameter of 87.36% of the DHAQ gelatin microspheres (DHAQ-GMS) was in the range of 5.1 to 25.0 microns. Release of the drug from the DHAQ-GMS in vitro became much slower and its t1/2 was 4 times longer than that of pure DHAQ. The characteristic peak of heat absorption on the differential thermal analysis curve was at 133 degrees C and almost no change was observed after the DHAQ-GMS were stored for 3 months at 37 degrees C (relative humidity 75%). The distribution test in vivo in mice indicated that the lung targeting effect of the DHAQ-GMS was obvious and that the targeting efficiency of the lung compared to other organs and blood increased 3 to 35 times. Kinetic behavior of the drug in mouse lung could be described by one open compartment model, and the average residual time increased by 10 h. | lld:pubmed |
| pubmed-article:7484159 | pubmed:language | chi | lld:pubmed |
| pubmed-article:7484159 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7484159 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7484159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7484159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7484159 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7484159 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7484159 | pubmed:issn | 0513-4870 | lld:pubmed |
| pubmed-article:7484159 | pubmed:author | pubmed-author:WangJ HJH | lld:pubmed |
| pubmed-article:7484159 | pubmed:author | pubmed-author:LoHH | lld:pubmed |
| pubmed-article:7484159 | pubmed:author | pubmed-author:PazR RRR | lld:pubmed |
| pubmed-article:7484159 | pubmed:author | pubmed-author:YUP MPM | lld:pubmed |
| pubmed-article:7484159 | pubmed:author | pubmed-author:ZhangZ RZR | lld:pubmed |
| pubmed-article:7484159 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7484159 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:7484159 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7484159 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7484159 | pubmed:pagination | 549-55 | lld:pubmed |
| pubmed-article:7484159 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7484159 | pubmed:meshHeading | pubmed-meshheading:7484159-... | lld:pubmed |
| pubmed-article:7484159 | pubmed:meshHeading | pubmed-meshheading:7484159-... | lld:pubmed |
| pubmed-article:7484159 | pubmed:meshHeading | pubmed-meshheading:7484159-... | lld:pubmed |
| pubmed-article:7484159 | pubmed:meshHeading | pubmed-meshheading:7484159-... | lld:pubmed |
| pubmed-article:7484159 | pubmed:meshHeading | pubmed-meshheading:7484159-... | lld:pubmed |
| pubmed-article:7484159 | pubmed:meshHeading | pubmed-meshheading:7484159-... | lld:pubmed |
| pubmed-article:7484159 | pubmed:meshHeading | pubmed-meshheading:7484159-... | lld:pubmed |
| pubmed-article:7484159 | pubmed:meshHeading | pubmed-meshheading:7484159-... | lld:pubmed |
| pubmed-article:7484159 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7484159 | pubmed:articleTitle | [Studies on lung targeting gelatin microspheres of mitoxantrone]. | lld:pubmed |
| pubmed-article:7484159 | pubmed:affiliation | School of Pharmacy, West China University of Medical Sciences, Chengdu. | lld:pubmed |
| pubmed-article:7484159 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7484159 | pubmed:publicationType | English Abstract | lld:pubmed |
| pubmed-article:7484159 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
