Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1.

Source:http://linkedlifedata.com/resource/pubmed/id/7479981

Proc. Natl. Acad. Sci. U.S.A. 1995 Nov 21 92 24 11289-93

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PMID
7479981