| pubmed-article:7479942 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7479942 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:7479942 | lifeskim:mentions | umls-concept:C1257743 | lld:lifeskim |
| pubmed-article:7479942 | lifeskim:mentions | umls-concept:C0072980 | lld:lifeskim |
| pubmed-article:7479942 | lifeskim:mentions | umls-concept:C1516670 | lld:lifeskim |
| pubmed-article:7479942 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:7479942 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:7479942 | pubmed:dateCreated | 1995-12-28 | lld:pubmed |
| pubmed-article:7479942 | pubmed:abstractText | Differentiating 3T3-L1 cells express an immunophilin early during the adipocyte conversion program as described in this issue [Yeh, W.-C., Li, T.-K., Bierer, B. E. & McKnight, S. L. (1995) Proc. Natl. Acad. Sci. USA 92, 11081-11085]. The temporal expression profile of this protein, designated FK506-binding protein (FKBP) 51, is concordant with the clonal-expansion period undertaken by 3T3-L1 cells after exposure to adipogenic hormones. Having observed FKBP51 synthesis early during adipogenesis, we tested the effects of three immunosuppressive drugs--cyclosporin A, FK506, and rapamycin--on the terminal-differentiation process. Adipocyte conversion was not affected by either cyclosporin A or FK506 and yet was significantly reduced by rapamycin at drug concentrations as low as 10 nM. Clonal expansion was impeded in drug-treated cultures, as was the accumulation of cytoplasmic lipid droplets normally seen late during differentiation. Rapamycin treatment likewise inhibited the expression of CCAAT/enhancer binding protein alpha, a transcription factor required for 3T3-L1 cell differentiation. All three of these effects were reversed by high FK506 concentrations, indicating that the operative inhibitory event was mediated by an immunophilin-rapamycin complex. | lld:pubmed |
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| pubmed-article:7479942 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7479942 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7479942 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7479942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7479942 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7479942 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7479942 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7479942 | pubmed:author | pubmed-author:McKnightS LSL | lld:pubmed |
| pubmed-article:7479942 | pubmed:author | pubmed-author:YeeW HWH | lld:pubmed |
| pubmed-article:7479942 | pubmed:author | pubmed-author:BiererB EBE | lld:pubmed |
| pubmed-article:7479942 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7479942 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:7479942 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7479942 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7479942 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7479942 | pubmed:pagination | 11086-90 | lld:pubmed |
| pubmed-article:7479942 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7479942 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7479942 | pubmed:articleTitle | Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. | lld:pubmed |
| pubmed-article:7479942 | pubmed:affiliation | Johns Hopkins University, Baltimore, MD 21205, USA. | lld:pubmed |
| pubmed-article:7479942 | pubmed:publicationType | Journal Article | lld:pubmed |
