| pubmed-article:7477407 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7477407 | lifeskim:mentions | umls-concept:C0037929 | lld:lifeskim |
| pubmed-article:7477407 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:7477407 | lifeskim:mentions | umls-concept:C0018282 | lld:lifeskim |
| pubmed-article:7477407 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:7477407 | lifeskim:mentions | umls-concept:C1753129 | lld:lifeskim |
| pubmed-article:7477407 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:7477407 | pubmed:issue | 6556 | lld:pubmed |
| pubmed-article:7477407 | pubmed:dateCreated | 1995-12-28 | lld:pubmed |
| pubmed-article:7477407 | pubmed:abstractText | There is little axonal growth after central nervous system (CNS) injury in adult mammals. The administration of antibodies (IN-1) to neutralize the myelin-associated neurite growth inhibitory proteins leads to long-distance regrowth of a proportion of CNS axons after injury. Our aim was: to determine if spinal cord lesion in adult rats, followed by treatment with antibodies to neurite growth inhibitors, can lead to regeneration and anatomical plasticity of other spinally projecting pathways; to determine if the anatomical projections persist at long survival intervals; and to determine whether this fibre growth is associated with recovery of function. We report here that brain stem-spinal as well as corticospinal axons undergo regeneration and anatomical plasticity after application of IN-1 antibodies. There is a recovery of specific reflex and locomotor functions after spinal cord injury in these adult rats. Removal of the sensorimotor cortex in IN-1-treated rats 2-3 months later abolished the recovered contact-placing responses, suggesting that the recovery was dependent upon the regrowth of these pathways. | lld:pubmed |
| pubmed-article:7477407 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7477407 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7477407 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7477407 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7477407 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7477407 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7477407 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7477407 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7477407 | pubmed:author | pubmed-author:SchwabM EME | lld:pubmed |
| pubmed-article:7477407 | pubmed:author | pubmed-author:GanEE | lld:pubmed |
| pubmed-article:7477407 | pubmed:author | pubmed-author:KIMS BSB | lld:pubmed |
| pubmed-article:7477407 | pubmed:author | pubmed-author:SchnellLL | lld:pubmed |
| pubmed-article:7477407 | pubmed:author | pubmed-author:BregmanB SBS | lld:pubmed |
| pubmed-article:7477407 | pubmed:author | pubmed-author:Kunkel-Bagden... | lld:pubmed |
| pubmed-article:7477407 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7477407 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:7477407 | pubmed:volume | 378 | lld:pubmed |
| pubmed-article:7477407 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7477407 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7477407 | pubmed:pagination | 498-501 | lld:pubmed |
| pubmed-article:7477407 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7477407 | pubmed:meshHeading | pubmed-meshheading:7477407-... | lld:pubmed |
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| pubmed-article:7477407 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7477407 | pubmed:articleTitle | Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. | lld:pubmed |
| pubmed-article:7477407 | pubmed:affiliation | Department of Cell Biology, Georgetown University Medical Center, Washington, DC 20007, USA. | lld:pubmed |
| pubmed-article:7477407 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7477407 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7477407 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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