| pubmed-article:7477268 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C1420476 | lld:lifeskim |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C0872265 | lld:lifeskim |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C0205099 | lld:lifeskim |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7477268 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:7477268 | pubmed:issue | 6551 | lld:pubmed |
| pubmed-article:7477268 | pubmed:dateCreated | 1995-11-24 | lld:pubmed |
| pubmed-article:7477268 | pubmed:abstractText | Eukaryotic cells respond to different extracellular stimuli by recruiting homologous signalling pathways that use members of the MEKK, MEK and ERK families of protein kinases. The MEKK-->MEK-->ERK core pathways of Saccharomyces cerevisiae may themselves be regulated by members of the STE20 family of protein kinases. Here we report specific activation of the mammalian stress-activated protein kinase (SAPK) pathway by germinal centre kinase (GCK), a human STE20 homologue. SAPKs, members of the ERK family, are activated in situ by inflammatory stimuli, including tumour-necrosis factor (TNF) and interleukin-1, and phosphorylate and probably stimulate the transactivation function of c-Jun. Although GCK is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal centre, where it may participate in B-cell differentiation. Activation of the SAPK pathway by GCK illustrates further the striking conservation of eukaryotic signalling mechanisms and defines the first physiological function of a mammalian Ste20. | lld:pubmed |
| pubmed-article:7477268 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7477268 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7477268 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7477268 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7477268 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7477268 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:KatzPP | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:AvruchJJ | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:KehrlJ HJH | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:WoodgettJ RJR | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:ForceTT | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:ZonL ILI | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:KyriakisJ MJM | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:SánchezII | lld:pubmed |
| pubmed-article:7477268 | pubmed:author | pubmed-author:PomboC MCM | lld:pubmed |
| pubmed-article:7477268 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7477268 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:7477268 | pubmed:volume | 377 | lld:pubmed |
| pubmed-article:7477268 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7477268 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7477268 | pubmed:pagination | 750-4 | lld:pubmed |
| pubmed-article:7477268 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7477268 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7477268 | pubmed:articleTitle | Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. | lld:pubmed |
| pubmed-article:7477268 | pubmed:affiliation | Diabetes Research Laboratory, Massachusetts General Hospital East, Charlestown, USA. | lld:pubmed |
| pubmed-article:7477268 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7477268 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7477268 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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