| pubmed-article:7391044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7391044 | lifeskim:mentions | umls-concept:C0027763 | lld:lifeskim |
| pubmed-article:7391044 | lifeskim:mentions | umls-concept:C0024334 | lld:lifeskim |
| pubmed-article:7391044 | lifeskim:mentions | umls-concept:C0034838 | lld:lifeskim |
| pubmed-article:7391044 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:7391044 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:7391044 | pubmed:dateCreated | 1980-9-23 | lld:pubmed |
| pubmed-article:7391044 | pubmed:abstractText | d-[3H]Lysergic acid diethylamide (LSD) bound to both dopamine- and serotonin (5HT)-sensitive sites in a particulate fraction derived from the central nervous system of the snail Helix pomatia. Conditions were found which enabled the two sites to be studied independently. [3H]LSD appeared to have a slightly higher affinity for dopamine-sensitive binding (Kd = 0.5 nM) than for 5HT-sensitive binding (Kd = 1.2 nM). A pharmacological analysis of the binding indicated that while dopamine- and 5HT-related agonists clearly discriminated between the two sites, putative antagonists showed little specificity for dopamine- or 5HT-sensitive binding. The pharmacology of 5HR-sensitive [3H]LSD binding was studied in relation to a 5HT-sensitive adenylate cyclase present in a particulate fraction derived from the same tissue. There was a very good correlation between the abilities of a range of agents to act as agonists or antagonists in the 5HT-sensitive adenylate cyclase assay and their abilities to displace 5HT-sensitive [3H]LSD binding (r = 0.94; p less than 0.001). In particular, d-LSD and a number of neurologic drugs were inhibitory in both assays in a stereoselective manner. These data suggest that in molluscan tissues, 5HT-sensitive [3H]LSD binding is related to the 5HT receptor which is coupled to adenylate cyclase. | lld:pubmed |
| pubmed-article:7391044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7391044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7391044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7391044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7391044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7391044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7391044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7391044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7391044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7391044 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7391044 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7391044 | pubmed:author | pubmed-author:LevitanI BIB | lld:pubmed |
| pubmed-article:7391044 | pubmed:author | pubmed-author:BucherFF | lld:pubmed |
| pubmed-article:7391044 | pubmed:author | pubmed-author:DrummondA HAH | lld:pubmed |
| pubmed-article:7391044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7391044 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:7391044 | pubmed:volume | 255 | lld:pubmed |
| pubmed-article:7391044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7391044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7391044 | pubmed:pagination | 6679-86 | lld:pubmed |
| pubmed-article:7391044 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
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| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:meshHeading | pubmed-meshheading:7391044-... | lld:pubmed |
| pubmed-article:7391044 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7391044 | pubmed:articleTitle | d-[3H]Lysergic acid diethylamide binding to serotonin receptors in the molluscan nervous system. | lld:pubmed |
| pubmed-article:7391044 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7391044 | lld:pubmed |
