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pubmed-article:7372404pubmed:abstractTextThe solid phase synthesis of alpha-melanocyte stimulating hormone (alpha-MSH) using the benzhydrylamine resin and a number of recently described side chain protecting groups is given. The carboxamide terminal peptide was obtained directly by treatment of the peptide resin with liquid hydrogen fluoride at 0 degrees in the presence of carbonium ion scavengers. The solid phase synthesis of the C-terminal carboxylate hormone, porcine beta-melanocyte stimulating hormone (beta p-MSH), using a 1% cross-linked Merrifield resin and the same side chain protecting groups as in the alpha-MSH synthesis also is presented. Purification of both peptides was carried out by conventional chromatographic techniques. Both hormones were fully active and beta p-MSH was slightly more potent than previously reported in the literature.lld:pubmed
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pubmed-article:7372404pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:7372404pubmed:year1980lld:pubmed
pubmed-article:7372404pubmed:articleTitleSynthesis of alpha- and beta-melanocyte stimulating hormones.lld:pubmed
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pubmed-article:7372404pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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