| pubmed-article:7332440 | pubmed:abstractText | Serum somatomedin activity was measured in 43 sera from 22 children aged 5 to 15 years operated on for a craniopharyngioma. All had a complete growth hormone deficiency and none received growth hormone therapy. At the time of the study, hydrocortisone therapy was given 29 times and thyroid powder 33 times. In these conditions, a highly significant correlation was found (r = 0.652, p less than 0.001) between somatomedin activity and growth velocity during the past three months. A negative correlation was also found with serum cortisol in patients who did not receive hydrocortisone (r = 0.654, P less than 0,05) and a positive correlation with serum concentrations of T4 (r = 0.640, p less than 0.05) and %3 (r = 0.956, p less than 0.001) in patients who did not receive thyroid powder. In contrast, no correlation was found with serum prolactin and insulin concentrations. These data establish than in children operated for craniopharyngioma, growth is related to a generation of somatomedin independent of growth hormone secretion, and closely controlled by endogenous secretions of cortisol and thyroid hormones. | lld:pubmed |
