| pubmed-article:7310745 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C0041214 | lld:lifeskim |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C0007974 | lld:lifeskim |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C0085361 | lld:lifeskim |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:7310745 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:7310745 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7310745 | pubmed:dateCreated | 1982-2-25 | lld:pubmed |
| pubmed-article:7310745 | pubmed:abstractText | A rapid in vitro prescreen for Fe-binding chelators has been developed with growth of Crithidia fasciculata and the sparing of its heme requirement in a defined medium as a test system. The prescreen functions as an index of chelator-mediated Fe transport and as an index of growth inhibition, presumably by the interference with Fe and/or heme metabolism at intracellular chelatable sites. Of 161 chelators examined, 84 were active heme-sparers; 32 of these inhibited growth at low chelator concentrations. Twenty-eight other chelators inhibited growth and another 49 were inactive. Such chelating activity directed at Fe and heme targets in hemoflagellates may provide leads for chemotherapy. | lld:pubmed |
| pubmed-article:7310745 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7310745 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7310745 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7310745 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7310745 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7310745 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7310745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7310745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7310745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7310745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7310745 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7310745 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7310745 | pubmed:issn | 0022-3921 | lld:pubmed |
| pubmed-article:7310745 | pubmed:author | pubmed-author:BacchiC JCJ | lld:pubmed |
| pubmed-article:7310745 | pubmed:author | pubmed-author:HutnerS HSH | lld:pubmed |
| pubmed-article:7310745 | pubmed:author | pubmed-author:KatzLL | lld:pubmed |
| pubmed-article:7310745 | pubmed:author | pubmed-author:ShapiroAA | lld:pubmed |
| pubmed-article:7310745 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7310745 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:7310745 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7310745 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7310745 | pubmed:pagination | 370-7 | lld:pubmed |
| pubmed-article:7310745 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:meshHeading | pubmed-meshheading:7310745-... | lld:pubmed |
| pubmed-article:7310745 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:7310745 | pubmed:articleTitle | Rapid in vitro prescreen for chelators as potential trypanocides based on growth of Crithidia fasciculata. | lld:pubmed |
| pubmed-article:7310745 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7310745 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7310745 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
