| pubmed-article:7284698 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7284698 | lifeskim:mentions | umls-concept:C0038661 | lld:lifeskim |
| pubmed-article:7284698 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:7284698 | lifeskim:mentions | umls-concept:C0751320 | lld:lifeskim |
| pubmed-article:7284698 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7284698 | pubmed:dateCreated | 1981-12-21 | lld:pubmed |
| pubmed-article:7284698 | pubmed:abstractText | 1 A number of aromatic-N-propargyl (acetylenic) compounds and indoleamines were tested for their inhibitory action on monoamine oxidase (MAO) type A and type B using the substrates 5-hydroxytryptamine (5-HT), beta-phenylethylamine (PEA) and dopamine. 2 Structure activity studies with aromatic-N-propragyl (acetylenic) derivatives have shown that MAO inhibitory potency is least dependent on the aromatic portion of the compounds. N-methylated propargyl derivatives are the most active and replacement of the methyl group with a higher alkyl or aromatic group results in significant reduction of activity. The triple bond in the N-propargyl portion is absolutely essential for activity and must be beta-to the nitrogen. It is the acetylenic group that gives these compounds their irreversible MAO inhibitory property. 3 The present study has indicated that since the acetylenic compounds resemble the enzyme substrates the distance between the aromatic ring and the N-propargyl terminal is crucial in designating the type A or type B MAO inhibitory property. For MAO type A inhibition, a distance equivalent to at least three carbon units is required, while for the inhibition of the B type enzyme this distance can be 1 or 2 carbon units. 4 The compounds AGN-1133 and AGN-1135 show most promise in Parkinson's disease or as anti-depressants because of their irreversible selective type B MAO inhibition in vitro and in vivo. 5 A number of indoleamine derivatives were found to be reversible selective type A inhibitors. | lld:pubmed |
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| pubmed-article:7284698 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7284698 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7284698 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7284698 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7284698 | pubmed:month | May | lld:pubmed |
| pubmed-article:7284698 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7284698 | pubmed:author | pubmed-author:YoudimM BMB | lld:pubmed |
| pubmed-article:7284698 | pubmed:author | pubmed-author:SabbaghAA | lld:pubmed |
| pubmed-article:7284698 | pubmed:author | pubmed-author:KalirAA | lld:pubmed |
| pubmed-article:7284698 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7284698 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:7284698 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7284698 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7284698 | pubmed:pagination | 55-64 | lld:pubmed |
| pubmed-article:7284698 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7284698 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:7284698 | pubmed:articleTitle | Selective acetylenic 'suicide' and reversible inhibitors of monoamine oxidase types A and B. | lld:pubmed |
| pubmed-article:7284698 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7284698 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7284698 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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