| pubmed-article:7277405 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7277405 | lifeskim:mentions | umls-concept:C0018533 | lld:lifeskim |
| pubmed-article:7277405 | lifeskim:mentions | umls-concept:C0441833 | lld:lifeskim |
| pubmed-article:7277405 | lifeskim:mentions | umls-concept:C0026377 | lld:lifeskim |
| pubmed-article:7277405 | lifeskim:mentions | umls-concept:C0024485 | lld:lifeskim |
| pubmed-article:7277405 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7277405 | lifeskim:mentions | umls-concept:C0070559 | lld:lifeskim |
| pubmed-article:7277405 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7277405 | pubmed:dateCreated | 1981-11-18 | lld:pubmed |
| pubmed-article:7277405 | pubmed:abstractText | Carbon-13 chemical shift (delta) and spin-lattice relaxation time (T1) measurements were used to determine the conformation around the Ar-OCH3 bond of the arylmethoxyl groups in a series of substituted phenethylamines. Methoxyl groups flanked by two ortho substituents have delta 13C values higher (60.5-62.5 ppm) than those with one or no ortho substituents ((55.5-57.5 ppm) and T1 values considerably longer than those of the other methoxyl groups in the same molecule. These measurements indicate that methoxyl groups with two ortho substituents acquire the out-of-plane conformation, while those with one or no ortho substitutents exist in the planar conformation. Phenethylamine analogues with methoxyl groups in the out-of-plane conformation have low or no psychotomimetic activity. A possible explanation is that the out-of-plane methoxyl group interferes with the binding of the electron-rich methoxy-substituted aromatic ring to a corresponding electron-deficient component on the active site of the receptor. | lld:pubmed |
| pubmed-article:7277405 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7277405 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7277405 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7277405 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7277405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7277405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7277405 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7277405 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7277405 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:7277405 | pubmed:author | pubmed-author:MakriyannisAA | lld:pubmed |
| pubmed-article:7277405 | pubmed:author | pubmed-author:KnittelJ JJJ | lld:pubmed |
| pubmed-article:7277405 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7277405 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:7277405 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7277405 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7277405 | pubmed:pagination | 906-9 | lld:pubmed |
| pubmed-article:7277405 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7277405 | pubmed:meshHeading | pubmed-meshheading:7277405-... | lld:pubmed |
| pubmed-article:7277405 | pubmed:meshHeading | pubmed-meshheading:7277405-... | lld:pubmed |
| pubmed-article:7277405 | pubmed:meshHeading | pubmed-meshheading:7277405-... | lld:pubmed |
| pubmed-article:7277405 | pubmed:meshHeading | pubmed-meshheading:7277405-... | lld:pubmed |
| pubmed-article:7277405 | pubmed:meshHeading | pubmed-meshheading:7277405-... | lld:pubmed |
| pubmed-article:7277405 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:7277405 | pubmed:articleTitle | Studies on phenethylamine hallucinogens. 2. Conformations of arylmethoxyl groups using 13C NMR. | lld:pubmed |
| pubmed-article:7277405 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7277405 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7277405 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:7277405 | lld:chembl |
