| pubmed-article:72612 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:72612 | lifeskim:mentions | umls-concept:C0026399 | lld:lifeskim |
| pubmed-article:72612 | lifeskim:mentions | umls-concept:C0007635 | lld:lifeskim |
| pubmed-article:72612 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:72612 | lifeskim:mentions | umls-concept:C0002198 | lld:lifeskim |
| pubmed-article:72612 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:72612 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:72612 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:72612 | pubmed:dateCreated | 1978-1-27 | lld:pubmed |
| pubmed-article:72612 | pubmed:abstractText | NRK cells and many other cultured fibroblasts were found to contain the protease inhibitor, alpha 2 macroglobulin (alpha 2M). This alpha 2M is present as a result of uptake of alpha 2M from the calf serum in the culture medium. Some of this alpha 2M is released back into the medium. In radiolabeling experiments with 14C-amino acids, no radioactivity was detected in intracellular or extracellular alpha 2M. Fluorescence microscopy of fixed cells using rhodamine-labeled antibodies indicated that alpha 2M is present in vesicular organelles different from primary lysosomes. Fluorescence microscopy of living cells shows that rhodamine-labeled alpha 2M (rhodamine-alpha 2M) is taken up into similar structures. Of the many cell lines examined, Moloney sarcoma virus-transformed cells had the lowest amounts of alpha 2M. Some of the effects of serum on the behavior of cultured cells could be a consequence of inhibition of cellular proteases by alpha 2M. | lld:pubmed |
| pubmed-article:72612 | pubmed:language | eng | lld:pubmed |
| pubmed-article:72612 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:72612 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:72612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:72612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:72612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:72612 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:72612 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:72612 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:72612 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:72612 | pubmed:author | pubmed-author:AndersonWW | lld:pubmed |
| pubmed-article:72612 | pubmed:author | pubmed-author:PastanII | lld:pubmed |
| pubmed-article:72612 | pubmed:author | pubmed-author:GalloMM | lld:pubmed |
| pubmed-article:72612 | pubmed:author | pubmed-author:WillinghamMM | lld:pubmed |
| pubmed-article:72612 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:72612 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:72612 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:72612 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:72612 | pubmed:pagination | 609-17 | lld:pubmed |
| pubmed-article:72612 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:72612 | pubmed:meshHeading | pubmed-meshheading:72612-Ce... | lld:pubmed |
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| pubmed-article:72612 | pubmed:meshHeading | pubmed-meshheading:72612-Rh... | lld:pubmed |
| pubmed-article:72612 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:72612 | pubmed:articleTitle | Localization of serum-derived alpha 2 macroglobulin in cultured cells and decrease after Moloney sarcoma virus transformation. | lld:pubmed |
| pubmed-article:72612 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:72612 | pubmed:publicationType | Comparative Study | lld:pubmed |
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