| pubmed-article:7236240 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7236240 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:7236240 | lifeskim:mentions | umls-concept:C0005270 | lld:lifeskim |
| pubmed-article:7236240 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:7236240 | lifeskim:mentions | umls-concept:C0026408 | lld:lifeskim |
| pubmed-article:7236240 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:7236240 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7236240 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7236240 | pubmed:dateCreated | 1981-7-23 | lld:pubmed |
| pubmed-article:7236240 | pubmed:abstractText | The carboxylic ionophore, monensin, blocks the migration of glycoprotein-containing vesicles from the Golgi region to the plasma membrane in fibroblasts resulting in an accumulation of secretory products in the Golgi cisternae. Treatment of cultured I-cell fibroblasts with monensin (0.5 muM) decreased the abnormal excretion of beta-hexosaminidase to 40% of untreated cultures within 15 min. A corresponding intracellular accumulation of the enzyme to greater than 200% of untreated cultured by 24 h was also observed. A small intracellular accumulation and slightly enhanced excretion of beta-hexosaminidase occurred in treated normal fibroblasts cultures. The intra- and extra-cellular distribution of newly synthesized beta-hexosaminidase in both monensin-treated normal and I-cell fibroblasts were electrophoretically indistinguishable from the four bands characteristic of I-cell intracellular beta-hexosaminidase. The excreted enzyme from both cultures was found to be a low- or no-uptake form. This form of beta-hexosaminidase may have been excreted from a secondary route preceding the site of the monensin effect. The similar findings in monensin-treated normal and I-cell cultures suggest that the subcellular site of the biochemical defect in I-cell disease is at a location after the site of the monensin effect i.e. late in the Golgi region or at a post-Golgi-region location. | lld:pubmed |
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| pubmed-article:7236240 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7236240 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7236240 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7236240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7236240 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7236240 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7236240 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:7236240 | pubmed:author | pubmed-author:RattazziM CMC | lld:pubmed |
| pubmed-article:7236240 | pubmed:author | pubmed-author:VladutiuG DGD | lld:pubmed |
| pubmed-article:7236240 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7236240 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7236240 | pubmed:volume | 192 | lld:pubmed |
| pubmed-article:7236240 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7236240 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7236240 | pubmed:pagination | 813-20 | lld:pubmed |
| pubmed-article:7236240 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7236240 | pubmed:meshHeading | pubmed-meshheading:7236240-... | lld:pubmed |
| pubmed-article:7236240 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7236240 | pubmed:articleTitle | The effect of monensin on beta-hexosaminidase transport in normal and I-cell fibroblasts. | lld:pubmed |
| pubmed-article:7236240 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7236240 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7236240 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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