| pubmed-article:7234871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7234871 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7234871 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:7234871 | lifeskim:mentions | umls-concept:C0025268 | lld:lifeskim |
| pubmed-article:7234871 | lifeskim:mentions | umls-concept:C0027662 | lld:lifeskim |
| pubmed-article:7234871 | lifeskim:mentions | umls-concept:C0031511 | lld:lifeskim |
| pubmed-article:7234871 | lifeskim:mentions | umls-concept:C0238767 | lld:lifeskim |
| pubmed-article:7234871 | lifeskim:mentions | umls-concept:C2745955 | lld:lifeskim |
| pubmed-article:7234871 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7234871 | pubmed:dateCreated | 1981-7-23 | lld:pubmed |
| pubmed-article:7234871 | pubmed:abstractText | Two kindreds with the multiple endocrine neoplasia type 2A syndrome were studied. Of one of these we examined 150 members, 20 of whom were treated with thyroidectomy for medullary carcinoma and nine with bilateral adrenalectomy for pheochromocytoma. Of the second kindred 50 members were examined, seven of whom were thyroidectomized and seven treated with bilateral adrenalectomy. Pheochromocytomas were invariably found on both sides, even in four cases in which the adrenals on one side appeared to be completely normal, not only at preoperative roentgenologic examination but also on inspection during the operation. The microscopic finding of micronodules and a cluster of abnormal medullary cells identical with those found in pheochromocytomas in one of the apparently normal adrenals represents a first stage in the development of diffuse medullary hyperplasia as well as nodular hyperplasia. This is in accordance with the fact that in the MEN type 2A syndrome pheochromocytomas are always multicentric and multiple in origin. On the basis of these findings we conclude that all patients with the MEN 2A syndrome who show symptoms and signs of active pheochromocytoma should be subjected to bilateral adrenalectomy, even when one or both of the adrenals appear to be normal at roentgenologic investigation. | lld:pubmed |
| pubmed-article:7234871 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7234871 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7234871 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7234871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7234871 | pubmed:month | May | lld:pubmed |
| pubmed-article:7234871 | pubmed:issn | 0002-9343 | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:StruyvenbergA... | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:WittebolPP | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:GeerdinkR ARA | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:HackengW HWH | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:LeoJ RJR | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:MinderW HWH | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:AllemanAA | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:KooikerC JCJ | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:Van der... | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:Van WaesP FPF | lld:pubmed |
| pubmed-article:7234871 | pubmed:author | pubmed-author:LipsK JKJ | lld:pubmed |
| pubmed-article:7234871 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7234871 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:7234871 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7234871 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7234871 | pubmed:pagination | 1051-60 | lld:pubmed |
| pubmed-article:7234871 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:meshHeading | pubmed-meshheading:7234871-... | lld:pubmed |
| pubmed-article:7234871 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:7234871 | pubmed:articleTitle | Bilateral occurrence of pheochromocytoma in patients with the multiple endocrine neoplasia syndrome type 2A (Sipple's syndrome). | lld:pubmed |
| pubmed-article:7234871 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7234871 | pubmed:publicationType | Case Reports | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7234871 | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7234871 | lld:pubmed |
