| pubmed-article:7180943 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7180943 | lifeskim:mentions | umls-concept:C0035579 | lld:lifeskim |
| pubmed-article:7180943 | lifeskim:mentions | umls-concept:C0005595 | lld:lifeskim |
| pubmed-article:7180943 | lifeskim:mentions | umls-concept:C0005847 | lld:lifeskim |
| pubmed-article:7180943 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:7180943 | lifeskim:mentions | umls-concept:C1704375 | lld:lifeskim |
| pubmed-article:7180943 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:7180943 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7180943 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:7180943 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7180943 | pubmed:dateCreated | 1983-2-14 | lld:pubmed |
| pubmed-article:7180943 | pubmed:abstractText | Growth plate morphometry and measurements of serum chemistry were correlated to clarify the pathogenesis of hypocalcemic and hypophosphatemic avian rickets. Accumulation of proliferating and maturing cartilage in hypocalcemic chicks is accompanied by increased length and increased variation in length of perforating epiphyseal vessels, decreased number and abnormal arrangement of marrow spaces, an increased proportion of cells to blood vessels in marrow spaces, and a change in the distribution but not the total number of DNA-synthesizing chondrocytes per unit width of growth plate. Accumulation of hypertrophic cartilage in hypophosphatemic rickets is accompanied by no change in length, distribution, or number of perforating epiphyseal vessels, elongation but no change in number or arrangement of marrow spaces, an increase in the relative proportion of blood vessels to cells in the marrow spaces, and no change in distribution but a decrease in total number of DNA-synthesizing chondrocytes per unit width of growth plate. Both types of rickets have decreased amounts of calcified cartilage. These results provide further evidence that hypocalcemia and hypophosphatemia cause morphologically distinct types of rickets in birds. The data indicate that the thickness of the proliferating and maturing region and hence the distance of the hypertrophic zones from the epiphysis are anatomically and temporally related to length of perforating epiphyseal vessels and serum calcium levels. They indicate that in hypocalcemic rickets accumulation of proliferating and maturing cartilage is unlikely to be the result of increased chondrocyte replication and that the relative rates of chondrocyte hypertrophy and resorption of hypertrophic cartilage by marrow are equal. They support the concept that delayed chondrocyte hypertrophy is the major cause of growth plate thickening in hypocalcemic rickets. Data presented in this study, when considered together with data from the literature on hypophosphatemic rickets, support the long-held concept that growth plate thickening in this disease is caused primarily by a decreased rate of resorption of hypertrophic cartilage by marrow relative to the rates of chondrocyte proliferation, maturation, and hypertrophy. The data further support the concepts that growth of cartilage into marrow is a biphasic process including longitudinal growth effected mainly by blood vessels, and resorption of the lateral walls of marrow spaces effected mainly by marrow cells, and that it is the latter phase that is defective in hypophosphatemia. | lld:pubmed |
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| pubmed-article:7180943 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7180943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7180943 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7180943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7180943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7180943 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7180943 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:7180943 | pubmed:author | pubmed-author:HufferW EWE | lld:pubmed |
| pubmed-article:7180943 | pubmed:author | pubmed-author:LaceyD LDL | lld:pubmed |
| pubmed-article:7180943 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7180943 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:7180943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7180943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7180943 | pubmed:pagination | 288-301 | lld:pubmed |
| pubmed-article:7180943 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7180943 | pubmed:meshHeading | pubmed-meshheading:7180943-... | lld:pubmed |
| pubmed-article:7180943 | pubmed:meshHeading | pubmed-meshheading:7180943-... | lld:pubmed |
| pubmed-article:7180943 | pubmed:meshHeading | pubmed-meshheading:7180943-... | lld:pubmed |
| pubmed-article:7180943 | pubmed:meshHeading | pubmed-meshheading:7180943-... | lld:pubmed |
| pubmed-article:7180943 | pubmed:meshHeading | pubmed-meshheading:7180943-... | lld:pubmed |
| pubmed-article:7180943 | pubmed:meshHeading | pubmed-meshheading:7180943-... | lld:pubmed |
| pubmed-article:7180943 | pubmed:meshHeading | pubmed-meshheading:7180943-... | lld:pubmed |
| pubmed-article:7180943 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7180943 | pubmed:articleTitle | Studies on the pathogenesis of avian rickets. I. Changes in epiphyseal and metaphyseal vessels in hypocalcemic and hypophosphatemic rickets. | lld:pubmed |
| pubmed-article:7180943 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7180943 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7180943 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7180943 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
