| pubmed-article:7171742 | pubmed:abstractText | Rat-liver parenchymal cells obtained in suspension by a mechanical method are shown to contain a cell-surface nuclease(s) that rapidly degrades exogenously added total Escherichia coli RNA. However, no acid-soluble products are formed; all the degradation products in the incubation medium sediment in the 4-5S RNA region on a sucrose density gradient. A part of the degraded RNA seems to be taken up by the cells; the uptake of the degradation products, presumably derived from rRNAs, is more than that of purified 4-5S RNA. Most of the RNA taken up by the cell sediments in the 4-5S region; only a small proportion is degraded to acid-soluble material within the cell. | lld:pubmed |
