| pubmed-article:7162516 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7162516 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7162516 | lifeskim:mentions | umls-concept:C0018555 | lld:lifeskim |
| pubmed-article:7162516 | lifeskim:mentions | umls-concept:C0014139 | lld:lifeskim |
| pubmed-article:7162516 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:7162516 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:7162516 | lifeskim:mentions | umls-concept:C0056170 | lld:lifeskim |
| pubmed-article:7162516 | lifeskim:mentions | umls-concept:C0128665 | lld:lifeskim |
| pubmed-article:7162516 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7162516 | pubmed:dateCreated | 1983-4-15 | lld:pubmed |
| pubmed-article:7162516 | pubmed:abstractText | A fungal metabolite, ML236B (Compactin), isolated from Penicillium citrinum, is a specific inhibitor of 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase (EC 1.1.1.34). Three ML236B-resistant (ML236Br) mutants, MF-1, MF-2, and MF-3, were isolated from V79 after N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis. The fluctuation test showed 2.2 X 10(-6) mutants per cell per generation of a spontaneous mutation frequency of ML236Br clones. These ML236Br clones showed a four- to fivefold-higher resistance to the drug than did their parental V79. Radioactive acetate, but not mevalonate, incorporation into the sterol fraction increased about 10-fold in ML236Br clones in comparison with that in V79. The cellular level of HMG-coenzyme A reductase in three ML236Br mutants was found to be a few-fold higher than that of V79 when cultured in the presence of lipoproteins. The 125I-labeled low-density lipoprotein-binding assay showed binding activity in three ML236Br clones comparable to that of the parental V79 cells. By contrast, an internalization assay of 125I-labeled low-density lipoprotein into the cells showed significantly reduced activity in three ML236Br clones in comparison with V79. | lld:pubmed |
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| pubmed-article:7162516 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7162516 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7162516 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7162516 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7162516 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7162516 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:7162516 | pubmed:author | pubmed-author:AkiyamaSS | lld:pubmed |
| pubmed-article:7162516 | pubmed:author | pubmed-author:MasudaAA | lld:pubmed |
| pubmed-article:7162516 | pubmed:author | pubmed-author:KuwanoMM | lld:pubmed |
| pubmed-article:7162516 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7162516 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:7162516 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7162516 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7162516 | pubmed:pagination | 1354-61 | lld:pubmed |
| pubmed-article:7162516 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7162516 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7162516 | pubmed:articleTitle | Chinese hamster cell mutant resistant to ML236B (Compactin) is defective in endocytosis of low-density lipo-protein. | lld:pubmed |
| pubmed-article:7162516 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7162516 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7162516 | lld:pubmed |
