| pubmed-article:7145093 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7145093 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:7145093 | lifeskim:mentions | umls-concept:C1622418 | lld:lifeskim |
| pubmed-article:7145093 | lifeskim:mentions | umls-concept:C1278872 | lld:lifeskim |
| pubmed-article:7145093 | lifeskim:mentions | umls-concept:C0459521 | lld:lifeskim |
| pubmed-article:7145093 | lifeskim:mentions | umls-concept:C0205753 | lld:lifeskim |
| pubmed-article:7145093 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7145093 | pubmed:dateCreated | 1983-1-19 | lld:pubmed |
| pubmed-article:7145093 | pubmed:abstractText | The possibility that opioid peptides and noradrenaline co-exist not only in the desheathed bundle of bovine splenic nerve which contains approximately 98% sympathetic C-fibers, but also in the population of large dense-cored noradrenergic vesicles from these fibers, has been investigated. The primary fraction of large dense-cored vesicles which can be prepared at about 85% purity has been further subjected to density gradient and fractional centrifugation procedures, including D2O-loading and unloading on modified second gradients, in an attempt to separate any minor population of particles which potentially could contain opioid peptides and contaminate the large dense-cored vesicle fraction. Measurement of opioid peptides, noradrenaline, dopamine and dopamine beta-hydroxylase activity supports the conclusion that opioid peptides are stored in the primary population of large dense-cord vesicles per se, rather than in a minor population of contaminating particles from cells other than sympathetic C-fibers. This conclusion has implications for exocytotic release and the physiological role of the opioid peptides intra- and extra-neuronally. Nerve vesicle opioid peptides have a size less than 5000 daltons, in contrast to the high proportion of large peptides containing enkephalin sequences in the bovine adrenal medulla. | lld:pubmed |
| pubmed-article:7145093 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7145093 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7145093 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7145093 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7145093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7145093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7145093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7145093 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7145093 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:7145093 | pubmed:author | pubmed-author:ViverosO HOH | lld:pubmed |
| pubmed-article:7145093 | pubmed:author | pubmed-author:KleinR LRL | lld:pubmed |
| pubmed-article:7145093 | pubmed:author | pubmed-author:WilsonS PSP | lld:pubmed |
| pubmed-article:7145093 | pubmed:author | pubmed-author:YangW HWH | lld:pubmed |
| pubmed-article:7145093 | pubmed:author | pubmed-author:DzielakD JDJ | lld:pubmed |
| pubmed-article:7145093 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7145093 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:7145093 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7145093 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7145093 | pubmed:pagination | 2255-61 | lld:pubmed |
| pubmed-article:7145093 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:meshHeading | pubmed-meshheading:7145093-... | lld:pubmed |
| pubmed-article:7145093 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7145093 | pubmed:articleTitle | Opioid peptides and noradrenaline co-exist in large dense-cored vesicles from sympathetic nerve. | lld:pubmed |
| pubmed-article:7145093 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7145093 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7145093 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7145093 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7145093 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7145093 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7145093 | lld:pubmed |
