| pubmed-article:713123 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C0036845 | lld:lifeskim |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C0014020 | lld:lifeskim |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:713123 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:713123 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:713123 | pubmed:dateCreated | 1979-1-26 | lld:pubmed |
| pubmed-article:713123 | pubmed:abstractText | Water-in-oil-in-water (w/o/w) emulsion developed in our laboratory is as effective as water-in-oil (w/o) emulsion of Freund's incomplete adjuvant (FIA) in the stimulation of antibody formation. The emulsion is prepared by redispersion of water-in-sesame oil emulsion of an antigen solution in phosphate buffered saline with emulsifier, Tween 80. The emulsion can be stored at 4 degrees C for at least 3 months without any evidence of change in the adjuvanticity and in the w/o/w state. Even a single injection of bovine serum albumin (BSA) in the w/o/w emulsion elicited a high antibody response in mice over the period of almost whole lifespan. 10 microgram BSA in w/o/w could stimulate antibody formation up to 2(12) in hemagglutination titer, while the same dose in free solution did not elicit any detectable antibody. The tissue reactions caused by the w/o/w emulsion at the injected site and in the regional lymph nodes were much less prominent than those by FIA. | lld:pubmed |
| pubmed-article:713123 | pubmed:language | eng | lld:pubmed |
| pubmed-article:713123 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:713123 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:713123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:713123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:713123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:713123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:713123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:713123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:713123 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:713123 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:713123 | pubmed:issn | 0021-5031 | lld:pubmed |
| pubmed-article:713123 | pubmed:author | pubmed-author:WatanabeTT | lld:pubmed |
| pubmed-article:713123 | pubmed:author | pubmed-author:KimuraJJ | lld:pubmed |
| pubmed-article:713123 | pubmed:author | pubmed-author:MatuhasiTT | lld:pubmed |
| pubmed-article:713123 | pubmed:author | pubmed-author:HatakeyamaSS | lld:pubmed |
| pubmed-article:713123 | pubmed:author | pubmed-author:OkayasuII | lld:pubmed |
| pubmed-article:713123 | pubmed:author | pubmed-author:NariuchiHH | lld:pubmed |
| pubmed-article:713123 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:713123 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:713123 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:713123 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:713123 | pubmed:pagination | 149-54 | lld:pubmed |
| pubmed-article:713123 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-A... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-M... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-W... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-A... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-L... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-E... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-F... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-S... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-A... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-F... | lld:pubmed |
| pubmed-article:713123 | pubmed:meshHeading | pubmed-meshheading:713123-A... | lld:pubmed |
| pubmed-article:713123 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:713123 | pubmed:articleTitle | Studies on the adjuvant effect of water-in-oil-in-water (w/o/w) emulsion of sesame oil. 1. Enhanced and persistent antibody formation by antigen incorporated into the water-in-oil-in-water emulsion. | lld:pubmed |
| pubmed-article:713123 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:713123 | pubmed:publicationType | Comparative Study | lld:pubmed |
