| pubmed-article:7106056 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7106056 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7106056 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7106056 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:7106056 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:7106056 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:7106056 | lifeskim:mentions | umls-concept:C0013832 | lld:lifeskim |
| pubmed-article:7106056 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7106056 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7106056 | pubmed:dateCreated | 1982-10-12 | lld:pubmed |
| pubmed-article:7106056 | pubmed:abstractText | The acute effect of low and high doses of dexamethasone on renal electrolyte excretion was examined in chronically (2--3 weeks) adrenalectomized rats and was compared with that of aldosterone. At the lowest effective dose (2 micrograms/100 g BW) dexamethasone injection produced a 70% increase in urinary potassium (K) excretion (0.99 +/- 0.06 to 1.70 +/- 0.20 mueq/min; P less than 0.005) but had no effect on sodium excretion. In contrast, low doses of aldosterone (2.5 micrograms/100 g BW) caused a significant decrease in urinary sodium excretion (6.23 +/- 1.2 to 2.75 +/- 0.7 mueq/min; P less than 0.01) but had no influence on renal potassium excretion (UKV). Higher doses of dexamethasone (10, 20 and 50 micrograms/100 g BW) produced a greater kaliuresis, increasing UKV by more than 100% over baseline and higher (P less than 0.05) than values after a low dose of dexamethasone, but again failed to lower sodium excretion. The increase in UKV after all doses of dexamethasone occurred in association with a significant increase in urinary K concentration; at higher doses of dexamethasone there was a variable increase in urine flow. The increase in UKV was not secondary to an increase in plasma K concentration nor was it associated with a rise in blood pressure or glomerular filtration rate after dexamethasone administration. These findings demonstrate that, in the adrenalectomized rat, acute administration of low and high doses of dexamethasone increases urinary K excretion without affecting sodium excretion. In contrast, aldosterone has little effect on K excretion but significantly decreases sodium excretion. These results indicate that the kaliuresis observed after dexamethasone cannot be attributed to a mineralocorticoid property of the hormone. | lld:pubmed |
| pubmed-article:7106056 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7106056 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7106056 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7106056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7106056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7106056 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7106056 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7106056 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:7106056 | pubmed:author | pubmed-author:DeFronzoR ARA | lld:pubmed |
| pubmed-article:7106056 | pubmed:author | pubmed-author:TylerKK | lld:pubmed |
| pubmed-article:7106056 | pubmed:author | pubmed-author:BiaJ MJM | lld:pubmed |
| pubmed-article:7106056 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7106056 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:7106056 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7106056 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7106056 | pubmed:pagination | 882-8 | lld:pubmed |
| pubmed-article:7106056 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:7106056 | pubmed:meshHeading | pubmed-meshheading:7106056-... | lld:pubmed |
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| pubmed-article:7106056 | pubmed:meshHeading | pubmed-meshheading:7106056-... | lld:pubmed |
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| pubmed-article:7106056 | pubmed:meshHeading | pubmed-meshheading:7106056-... | lld:pubmed |
| pubmed-article:7106056 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7106056 | pubmed:articleTitle | The effect of dexamethasone on renal electrolyte excretion in the adrenalectomized rat. | lld:pubmed |
| pubmed-article:7106056 | pubmed:publicationType | Journal Article | lld:pubmed |
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