| pubmed-article:7093530 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7093530 | lifeskim:mentions | umls-concept:C0240321 | lld:lifeskim |
| pubmed-article:7093530 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:7093530 | lifeskim:mentions | umls-concept:C0002312 | lld:lifeskim |
| pubmed-article:7093530 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7093530 | pubmed:dateCreated | 1982-9-10 | lld:pubmed |
| pubmed-article:7093530 | pubmed:abstractText | We used restriction endonuclease analysis to determine the incidence of alpha-thalassemia in two Mediterranean islands. In a random population sample, the gene frequency of deletion-type alpha-thalassemia-2 (-alpha) was 0.18 in Sardinians and 0.07 in Greek Cypriots. All cases were the rightward crossover type. From these frequencies and the known incidence of hemoglobin-H disease in these populations, we calculated the frequency of the alpha-thalassemia-1 genotype (--) and determined that it was low. We also found that beta-thalassemia homozygotes in sardinia have a higher incidence of alpha-thalassemia than normals and beta thalassemia heterozygotes because a significantly greater number of these homozygotes are also homozygous for the alpha-thalassemia-2 lesion. These findings support the theory that coinheritance of alpha-thalassemia mitigates the severity of beta-thalassemia and suggest that the protection is most pronounced when two alpha-globin genes are deleted. | lld:pubmed |
| pubmed-article:7093530 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7093530 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7093530 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7093530 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7093530 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7093530 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7093530 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7093530 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7093530 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:LeeK YKY | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:Stamatoyannop... | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:CauGG | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:KanY WYW | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:DozyA MAM | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:FurbettaMM | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:AngiusAA | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:HadjiminasM... | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:ZachariadesZZ | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:RosatelliCC | lld:pubmed |
| pubmed-article:7093530 | pubmed:author | pubmed-author:PirastuMM | lld:pubmed |
| pubmed-article:7093530 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7093530 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:7093530 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7093530 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7093530 | pubmed:pagination | 509-12 | lld:pubmed |
| pubmed-article:7093530 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7093530 | pubmed:meshHeading | pubmed-meshheading:7093530-... | lld:pubmed |
| pubmed-article:7093530 | pubmed:meshHeading | pubmed-meshheading:7093530-... | lld:pubmed |
| pubmed-article:7093530 | pubmed:meshHeading | pubmed-meshheading:7093530-... | lld:pubmed |
| pubmed-article:7093530 | pubmed:meshHeading | pubmed-meshheading:7093530-... | lld:pubmed |
| pubmed-article:7093530 | pubmed:meshHeading | pubmed-meshheading:7093530-... | lld:pubmed |
| pubmed-article:7093530 | pubmed:meshHeading | pubmed-meshheading:7093530-... | lld:pubmed |
| pubmed-article:7093530 | pubmed:meshHeading | pubmed-meshheading:7093530-... | lld:pubmed |
| pubmed-article:7093530 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7093530 | pubmed:articleTitle | Alpha-thalassemia in two Mediterranean populations. | lld:pubmed |
| pubmed-article:7093530 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7093530 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7093530 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7093530 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7093530 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7093530 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7093530 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7093530 | lld:pubmed |
