| pubmed-article:7089371 | pubmed:abstractText | Erythrocyte surface and free serum sialic acid concentrations were determined during experimental Trypanosoma vivax infection in cattle. All infected calves developed mild trypanosomiasis, with significant decreases in mean packed cell volume occurring 15, 16, 20, 22 and 24 days after infection. The anaemia was preceded by significant decreases in mean erythrocyte surface sialic acid concentrations on days 7, 13 and 14, with yet another significant decrease on day 31 after infection. These decreases in erythrocyte surface sialic acid concentrations coincided with the parasitaemic waves. Free serum sialic acid concentration, however, showed an increase, though non-significantly, on day 8, which coincided with both a decrease in erythrocyte surface sialic acid and the initial parasitaemic wave. It is postulated that the early anaemia observed in infected animals may be attributable to the activities of the circulating trypanosomes which produce neuraminidase which, in turn, cleaves off surface sialic acid, thus rendering the erythrocyte more prone to phagocytosis by the recticuloendothelial system. | lld:pubmed |
