| pubmed-article:7086829 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7086829 | lifeskim:mentions | umls-concept:C1522564 | lld:lifeskim |
| pubmed-article:7086829 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:7086829 | lifeskim:mentions | umls-concept:C0004015 | lld:lifeskim |
| pubmed-article:7086829 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:7086829 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:7086829 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:7086829 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7086829 | pubmed:dateCreated | 1982-8-7 | lld:pubmed |
| pubmed-article:7086829 | pubmed:abstractText | Sterile, pyrogen-free L-[4-11C]aspartic acid was prepared from 11CO2 using phosphoenolpyruvate carboxylase and glutamic/oxaloacetic acid transaminase immobilized on Sepharose supports to determine if it is a useful indicator for in vivo, noninvasive determination of myocardial metabolism. An intracoronary bolus injection of L-[4-11C]aspartic acid into dog myocardium showed a triexponential clearance curve with maximal production of 11CO2 100 s after injection. Inactivation of myocardial transaminase activity modified the tracer clearance and inhibited the production of 11CO2. Positron-computed tomography imaging showed that the 11C activities retained in rhesus monkey myocardium are higher than those observed in dog heart after intravenous injection of L-[4-11C]aspartic acid. These findings demonstrated the rapid incorporation of the carbon skeleton of L-aspartic acid into the tricarboxylic acid cycle after enzymatic transamination in myocardium and suggested that L-[4-11C]aspartic acid could be of value for in vivo, noninvasive assessment of local myocardial metabolism. | lld:pubmed |
| pubmed-article:7086829 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7086829 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7086829 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7086829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7086829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7086829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7086829 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7086829 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7086829 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7086829 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:7086829 | pubmed:author | pubmed-author:BarrioJ RJR | lld:pubmed |
| pubmed-article:7086829 | pubmed:author | pubmed-author:SchelbertH... | lld:pubmed |
| pubmed-article:7086829 | pubmed:author | pubmed-author:HenzeEE | lld:pubmed |
| pubmed-article:7086829 | pubmed:author | pubmed-author:BaumgartnerF... | lld:pubmed |
| pubmed-article:7086829 | pubmed:author | pubmed-author:EgbertJ EJE | lld:pubmed |
| pubmed-article:7086829 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7086829 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:7086829 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7086829 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7086829 | pubmed:pagination | 93-6 | lld:pubmed |
| pubmed-article:7086829 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7086829 | pubmed:meshHeading | pubmed-meshheading:7086829-... | lld:pubmed |
| pubmed-article:7086829 | pubmed:meshHeading | pubmed-meshheading:7086829-... | lld:pubmed |
| pubmed-article:7086829 | pubmed:meshHeading | pubmed-meshheading:7086829-... | lld:pubmed |
| pubmed-article:7086829 | pubmed:meshHeading | pubmed-meshheading:7086829-... | lld:pubmed |
| pubmed-article:7086829 | pubmed:meshHeading | pubmed-meshheading:7086829-... | lld:pubmed |
| pubmed-article:7086829 | pubmed:meshHeading | pubmed-meshheading:7086829-... | lld:pubmed |
| pubmed-article:7086829 | pubmed:meshHeading | pubmed-meshheading:7086829-... | lld:pubmed |
| pubmed-article:7086829 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7086829 | pubmed:articleTitle | L-[4-11C]aspartic acid: enzymatic synthesis, myocardial uptake, and metabolism. | lld:pubmed |
| pubmed-article:7086829 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7086829 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
