| pubmed-article:7032769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7032769 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7032769 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:7032769 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:7032769 | lifeskim:mentions | umls-concept:C2362651 | lld:lifeskim |
| pubmed-article:7032769 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:7032769 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7032769 | pubmed:dateCreated | 1982-3-13 | lld:pubmed |
| pubmed-article:7032769 | pubmed:abstractText | Anti-T cell autoantibodies were detected in some aged humans. Non-immunoglobulin-bearing (Ig-) cells were isolated from the peripheral blood of normal human donors by negative selection through Ficoll, using sheep erythrocytes coated with rabbit anti-human Ig. The Ig- cells were then reacted with sera from 83 individuals ranging in age from 60 to 99 years; 36% of the serum samples were noticeably reactive with the Ig- cells (average reactivity 28%). The peripheral blood lymphocytes from some of the aged individuals were also tested for levels of Ig-secreting cells in a reverse haemolytic plaque assay; there was a six- to eight-fold increase in the number of plaque-forming cells (PFC) from those individuals whose sera contained appreciable amounts of anti-T cell antibody, as compared with those whose sera contained little or no anti-T cell antibody. Isolated Ig- cells from these individuals were also examined for the presence of regulatory T cell subsets, using sera from juvenile rheumatoid arthritis (JRA) patients. The Ig- cells from the subjects who had no detectable anti-T cell antibodies in their sera and near normal PFC levels were reactive with the JRA sera, whereas the Ig- cells from individuals with increased numbers of PFC and with serum anti-T cell antibodies were only slightly reactive with the JRA sera. These data suggest that a majority of the regulatory JRA+ subset of T cells had been lost in the latter group. When sera from aged individuals containing anti-T cell autoantibodies were reacted with JRA-, Ig- cells isolated from a normal human donor, little positive reactivity was seen, indicating that the autoantibodies in sera from aged humans and from some JRA patients are directed against similar T cell subsets. | lld:pubmed |
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| pubmed-article:7032769 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7032769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7032769 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7032769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7032769 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7032769 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:7032769 | pubmed:author | pubmed-author:YunisE JEJ | lld:pubmed |
| pubmed-article:7032769 | pubmed:author | pubmed-author:StrelkauskasA... | lld:pubmed |
| pubmed-article:7032769 | pubmed:author | pubmed-author:AndrewJ AJA | lld:pubmed |
| pubmed-article:7032769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7032769 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:7032769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7032769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7032769 | pubmed:pagination | 308-15 | lld:pubmed |
| pubmed-article:7032769 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7032769 | pubmed:meshHeading | pubmed-meshheading:7032769-... | lld:pubmed |
| pubmed-article:7032769 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:7032769 | pubmed:articleTitle | Autoantibodies to a regulatory T cell subset in human ageing. | lld:pubmed |
| pubmed-article:7032769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7032769 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
