| pubmed-article:701795 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:701795 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:701795 | lifeskim:mentions | umls-concept:C0009498 | lld:lifeskim |
| pubmed-article:701795 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:701795 | lifeskim:mentions | umls-concept:C0750729 | lld:lifeskim |
| pubmed-article:701795 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:701795 | lifeskim:mentions | umls-concept:C2062416 | lld:lifeskim |
| pubmed-article:701795 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:701795 | pubmed:dateCreated | 1978-12-29 | lld:pubmed |
| pubmed-article:701795 | pubmed:abstractText | The course of Sindbis virus infection in 12-day-old BALB/c mice was altered significantly in animals depleted of the third component of complement (C3) by treatment with purified cobra venom factor (CoVF). Although the same percentage of C3-depleted and normal animals died (30%) after the subcutaneous inoculation of 1000 PFU Sindbis virus, the mean day of death was later in C3-depleted mice (8.4 days) than in controls (6.5 days). In addition, morbidity was prolonged in C3-depleted mice. Growth of virus at the inoculation site in the foot was not different; however, viremia was prolonged and the amount of virus in the brain was 1000-fold greater 6 days after infection in C3-depleted animals. These studies demonstrated that complement plays an important role in the host's response to Sindbis virus infection by participating in both beneficial and immunopathologic responses to the infection. | lld:pubmed |
| pubmed-article:701795 | pubmed:language | eng | lld:pubmed |
| pubmed-article:701795 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:701795 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:701795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:701795 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:701795 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:701795 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:701795 | pubmed:author | pubmed-author:WinkelsteinJ... | lld:pubmed |
| pubmed-article:701795 | pubmed:author | pubmed-author:HirschR LRL | lld:pubmed |
| pubmed-article:701795 | pubmed:author | pubmed-author:GriffinD EDE | lld:pubmed |
| pubmed-article:701795 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:701795 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:701795 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:701795 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:701795 | pubmed:pagination | 1276-8 | lld:pubmed |
| pubmed-article:701795 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:701795 | pubmed:meshHeading | pubmed-meshheading:701795-C... | lld:pubmed |
| pubmed-article:701795 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:701795 | pubmed:articleTitle | The effect of complement depletion on the course of Sindbis virus infection in mice. | lld:pubmed |
| pubmed-article:701795 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:701795 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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